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Tbio
P0C7T4
Minor histocompatibility protein HMSD variant form

Protein Summary
Description
This allelic splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000526932
  • ENSP00000431632
  • ENSG00000221887

Symbol
  • C18orf53
  • ACC6
  • ACC-6
  • HSMD-v
  • C18orf53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
histone modification site profile
0.6
transcription factor binding site profile
0.42
cell line
0.39
transcription factor
0.38


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.52   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.52   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
ZNF419
Tdark
Family:  TF
Novelty:  0.69013025
Score:  0.654
Data Source:  STRINGDB
IL2RG
Tclin
Novelty:  0.00108272
Score:  0.643
Data Source:  STRINGDB
SERPINI1
Tbio
Novelty:  0.00518205
Score:  0.604
Data Source:  STRINGDB
CTSH
Tchem
Family:  Enzyme
Novelty:  0.00336694
Score:  0.592
Data Source:  STRINGDB
SERPINF2
Tbio
Novelty:  0.00054719
Score:  0.549
Data Source:  STRINGDB
SERPING1
Tbio
Family:  Enzyme
Novelty:  0.00068448
Score:  0.538
Data Source:  STRINGDB
SERPINE3
Tdark
Novelty:  0.82922603
Score:  0.512
Data Source:  STRINGDB
SERPINE2
Tbio
Novelty:  0.00246375
Score:  0.504
Data Source:  STRINGDB
SERPINH1
Tbio
Novelty:  0.00106715
Score:  0.483
Data Source:  STRINGDB
SERPIND1
Tbio
Novelty:  0.00120897
Score:  0.482
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histocompatibility minor serpin domain containing
VGNC:10015
100615826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histocompatibility minor serpin domain containing
Publication Statistics
PubMed Score 29.52
PubMed score by year
PubTator Score 6.96
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title