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Tbio
ARMS2
Age-related maculopathy susceptibility protein 2

Protein Summary
Description
This gene encodes a small secreted protein specific to primates. This protein is a component of the choroidal extracellular matrix of the eye. Mutations in this gene are associated with age-related macular degeneration. [provided by RefSeq, Sep 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000528446
  • ENSP00000436682
  • ENSG00000254636

Symbol
  • ARMD8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.86
cell line
0.68
phenotype
0.66
disease
0.63
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.72   (req: < 5)
Gene RIFs: 179   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.72   (req: >= 5)
Gene RIFs: 179   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
15
9
1
2.2
99.8
5
3
0
2.3
98.2
atrophic macular degeneration
3
2
0
2.5
96.2
8
5
4
1.1
90.8
disease progression measurement
1
1
0
2.1
83
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2.2
99.8
0
2.3
98.2
atrophic macular degeneration
0
2.5
96.2
4
1.1
90.8
disease progression measurement
0
2.1
83
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0C7Q2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Protein-Protein Interactions (41)
1 – 10 of 41
CFH
Tbio
Novelty:  0.00065547
Score:  0.922
Data Source:  STRINGDB
CFB
Tchem
Novelty:  0.00102672
Score:  0.835
Data Source:  STRINGDB
PLEKHA1
Tbio
Novelty:  0.03634462
Score:  0.804
Data Source:  STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.79
Data Source:  STRINGDB
JPT1
Tbio
Novelty:  0.01341629
Score:  0.789
Data Source:  STRINGDB
HTRA1
Tchem
Family:  Enzyme
Novelty:  0.0016879
Score:  0.787
Data Source:  STRINGDB
HMCN1
Tbio
Novelty:  0.03556137
Score:  0.719
Data Source:  STRINGDB
CFI
Tbio
Novelty:  0.00271423
Score:  0.709
Data Source:  STRINGDB
LIPC
Tchem
Family:  Enzyme
Novelty:  0.00219107
Score:  0.7
Data Source:  STRINGDB
CFHR3
Tbio
Novelty:  0.01779009
Score:  0.67
Data Source:  STRINGDB
Publication Statistics
PubMed Score  240.72

PubMed score by year
PubTator Score  173.89

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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