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Tdark
KRTAP2-3
Keratin-associated protein 2-3

Protein Summary
Description
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391418
  • ENSP00000375237
  • ENSG00000212724
  • ENST00000570303
  • ENSP00000459261
  • ENSG00000262862

Symbol
  • KAP2.3
  • KRTAP2.3
  • KAP2.3
  • KAP2.4
  • KRTAP2-4
  • KRTAP2.3
  • KRTAP2.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.69   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 1   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.69   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair shape measurement
1
1
1
5.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair shape measurement
1
5.3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P0C7H8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (76)
1 – 10 of 76
KRTAP3-2
Tdark
Novelty: 1.99836821
Score: 0.667
Data Source: STRINGDB
KRTAP24-1
Tdark
Novelty: 0.3470695
Score: 0.604
Data Source: STRINGDB
KRTAP26-1
Tdark
Novelty: 0.48053029
Score: 0.569
Data Source: STRINGDB
YAE1
Tbio
Novelty: 0.65114343
Score: 0.556
Data Source: STRINGDB
KRTAP7-1
Tdark
Novelty: 0.31372157
Score: 0.548
Data Source: STRINGDB
KRTAP4-1
Tdark
Novelty: 20.19886991
Score: 0.543
Data Source: STRINGDB
KRTAP22-1
Tdark
Novelty: 0.75498951
Score: 0.539
Data Source: STRINGDB
KRTAP6-3
Tdark
Novelty: 0.28055117
Score: 0.536
Data Source: STRINGDB
KRTAP11-1
Tbio
Novelty: 0.20865014
Score: 0.533
Data Source: STRINGDB
KRTAP13-3
Tdark
Novelty: 0.50342897
Score: 0.533
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.69

PubMed score by year
PubTator Score  0.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer