Tbio H2AFB1 Histone H2A-Bbd type 1

Protein Summary

Description

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134). Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. This gene is part of a region that is repeated three times on chromosome X, once in intron 22 of the F8 gene and twice closer to the Xq telomere. This record represents the most centromeric copy which is in intron 22 of the F8 gene. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• P0C5Y9
• A0PK90
• P98176
• Q5TZB2
• Q6FG78
• Q96PR7

Gene Name

• H2AFB1

Ensembl ID

• ENST00000620016
• ENSP00000484261
• ENSG00000274183

Symbol

• H2A.B
• H2A.Bbd

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.99
cellular component	0.71
disease	0.52
tissue	0.45
protein domain	0.41

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H2a-bbd Type 1

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Histone / Histone H2a-bbd Type 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 51   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (353)

Explore Interacting Targets

1 – 10 of 353

• See Interactions on String-DB

RAB15

Tbio

Family:  Enzyme

Novelty:  0.10493742

p_int:  0.999102332

p_ni:  8.39e-7

p_wrong:  0.000896829

Data Source:  BioPlex

CHCHD2

Tbio

Novelty:  0.01615338

p_int:  0.997751162

p_ni:  0.001031983

p_wrong:  0.001216855

Data Source:  BioPlex

TEX10

Tdark

Novelty:  0.12988812

p_int:  0.996662246

p_ni:  0.003337753

p_wrong:  1e-9

Data Source:  BioPlex

MDM2

Tchem

Family:  Enzyme

Novelty:  0.00028385

p_int:  0.965155024

p_ni:  0.034844976

Data Source:  BioPlex

C1QBP

Tbio

Novelty:  0.00532825

p_int:  0.937787728

p_ni:  0.062212272

Data Source:  BioPlex

UBB

Tbio

Novelty:  0.00661254

p_int:  0.933786881

p_ni:  0.066212028

p_wrong:  0.000001092

Score:  0.318

Data Source:  BioPlex,STRINGDB

NOL9

Tdark

Family:  Enzyme

Novelty:  0.05830272

p_int:  0.915920053

p_ni:  0.084079947

Data Source:  BioPlex

BAG1

Tbio

Novelty:  0.00285515

p_int:  0.905111047

p_ni:  0.094888242

p_wrong:  7.11e-7

Data Source:  BioPlex

SENP3

Tbio

Family:  Enzyme

Novelty:  0.00374663

p_int:  0.871748939

p_ni:  0.128250759

p_wrong:  3.02e-7

Data Source:  BioPlex

YBEY

Tdark

Family:  Enzyme

Novelty:  0.02778029

p_int:  0.810745649

p_ni:  0.189212124

p_wrong:  0.000042227

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (79)

Reactome (73)

KEGG (3)

WikiPathways (3)

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 73

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Amyloid fiber formation	79 targets	R-HSA-977225
Reactome	B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Name	Explore in Pharos	Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36 targets	R-HSA-5625886
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Amyloid fiber formation	79 targets	R-HSA-977225
B-WICH complex positively regulates rRNA expression	61 targets	R-HSA-5250924

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (4)

Processes (3)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein heterodimerization activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
erythrocyte count	EFO_0004305	1	1	1		50.6
hemoglobin measurement	EFO_0004509	1	1	1		50.6
hematocrit	EFO_0004348	1	1	1		50.6
leukocyte count	EFO_0004308	1	1	1		50.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
erythrocyte count	EFO_0004305	1		50.6
hemoglobin measurement	EFO_0004509	1		50.6
hematocrit	EFO_0004348	1		50.6
leukocyte count	EFO_0004308	1		50.6

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Chromosome
Complete proteome
DNA-binding
mRNA processing
Nucleosome core
Nucleus
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
erythrocyte count
hematocrit
hemoglobin measurement
leukocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (2)

1 – 2 of 2

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Rat	H2A histone family, member B3	RGD:1561666	302783
Cow	histone H2A-Bbd (H2A Barr body-deficient)-like		528006

Species	Name	OMA	EggNOG	Inparanoid
Rat	H2A histone family, member B3
Cow	histone H2A-Bbd (H2A Barr body-deficient)-like

Publication Statistics

PubMed Score 13.72

PubMed score by year

Reset Zoom

Related Publications

Text Mined References (9)

Items per page:

10

0 of 0

PMID	Year	Title