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Tbio
H2AFB1
Histone H2A-Bbd type 1

Protein Summary
Description
Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134). Histones are basic nuclear proteins that are re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620016
  • ENSP00000484261
  • ENSG00000274183

Symbol
  • H2A.B
  • H2A.Bbd
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
cellular component
0.71
disease
0.52
tissue
0.45
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (353)
RAB15
Tbio
Family:  Enzyme
Novelty:  0.10493742
p_int:  0.999102332
p_ni:  8.39e-7
p_wrong:  0.000896829
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.997751162
p_ni:  0.001031983
p_wrong:  0.001216855
Data Source:  BioPlex
TEX10
Tdark
Novelty:  0.12988812
p_int:  0.996662246
p_ni:  0.003337753
p_wrong:  1e-9
Data Source:  BioPlex
MDM2
Tchem
Family:  Enzyme
Novelty:  0.00028385
p_int:  0.965155024
p_ni:  0.034844976
Data Source:  BioPlex
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.937787728
p_ni:  0.062212272
Data Source:  BioPlex
UBB
Tbio
Novelty:  0.00661254
p_int:  0.933786881
p_ni:  0.066212028
p_wrong:  0.000001092
Score:  0.318
Data Source:  BioPlex,STRINGDB
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
p_int:  0.915920053
p_ni:  0.084079947
Data Source:  BioPlex
BAG1
Tbio
Novelty:  0.00285515
p_int:  0.905111047
p_ni:  0.094888242
p_wrong:  7.11e-7
Data Source:  BioPlex
SENP3
Tbio
Family:  Enzyme
Novelty:  0.00374663
p_int:  0.871748939
p_ni:  0.128250759
p_wrong:  3.02e-7
Data Source:  BioPlex
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.810745649
p_ni:  0.189212124
p_wrong:  0.000042227
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (79)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (R-HSA-5625886)

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Find Similar Targets
Items per page:
1 – 5 of 73
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Amyloid fiber formation
Reactome
B-WICH complex positively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Amyloid fiber formation
B-WICH complex positively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythrocyte count
1
1
1
50.6
hemoglobin measurement
1
1
1
50.6
hematocrit
1
1
1
50.6
leukocyte count
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erythrocyte count
1
50.6
hemoglobin measurement
1
50.6
hematocrit
1
50.6
leukocyte count
1
50.6
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 13.72
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title