Tbio TFPT TCF3 fusion partner

Protein Summary

Description

Appears to promote apoptosis in a p53/TP53-independent manner. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Uniprot Accession IDs

• P0C1Z6
• G5E9B5

Gene Name

• TFPT

Ensembl ID

• ENST00000391758
• ENSP00000375638
• ENSG00000105619
• ENST00000391759
• ENSP00000375639
• ENST00000611344
• ENSP00000484338
• ENSG00000276504
• ENST00000616798
• ENSP00000480169

Symbol

• INO80F
• FB1
• amida
• INO80F

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.96
histone modification site profile	0.92
kinase perturbation	0.81
transcription factor binding site profile	0.77
cellular component	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.63   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.63   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0