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Tbio
WEE2
Wee1-like protein kinase 2

Protein Summary
Description
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397541
  • ENSP00000380675
  • ENSG00000214102
  • ENST00000574659
  • ENSP00000459392
  • ENSG00000263042

Symbol
  • WEE1B
  • OOMD5
  • WEE1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
biological process
0.75
protein domain
0.73
microRNA
0.51
biological term
0.45


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3027899
381759
Rat
RGD:1587197
502750
Dog
WEE1 homolog 2
VGNC:48403
475525
Cow
WEE1 homolog 2
VGNC:36931
520049
Pig
WEE1 homolog 2
100048934
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
WEE1 homolog 2
Cow
WEE1 homolog 2
Pig
WEE1 homolog 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0C1S8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (84)
1 – 10 of 84
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.919
Data Source: STRINGDB
CDC25B
Tchem
Family: Enzyme
Novelty: 0.00378458
Score: 0.838
Data Source: STRINGDB
WEE1
Tchem
Family: Kinase
Novelty: 0.00162432
Score: 0.81
Data Source: STRINGDB
CDC25A
Tchem
Family: Enzyme
Novelty: 0.00250149
Score: 0.726
Data Source: STRINGDB
CDC25C
Tchem
Family: Enzyme
Novelty: 0.00227769
Score: 0.709
Data Source: STRINGDB
FBXO43
Tbio
Novelty: 0.04056148
Score: 0.686
Data Source: STRINGDB
CCNB1
Tchem
Novelty: 0.0005503
Score: 0.66
Data Source: STRINGDB
FZR1
Tbio
Novelty: 0.01599606
Score: 0.65
Data Source: STRINGDB
BTG4
Tbio
Novelty: 0.04499244
Score: 0.645
Data Source: STRINGDB
CDC20
Tbio
Novelty: 0.00197887
Score: 0.619
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.82

PubMed score by year
PubTator Score  5.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer