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Tbio
HIST1H2AG
Histone H2A type 1

Protein Summary
Description
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358739
  • ENSP00000351589
  • ENSG00000196747
  • ENST00000359193
  • ENSP00000352119
  • ENSG00000196787
  • ENST00000359611
  • ENSP00000352627
  • ENSG00000278677
  • ENST00000613174
  • ENSP00000482538
  • ENSG00000276903
  • ENST00000618958
  • ENSP00000482431
  • ENSG00000275221

Symbol
  • H2AFP
  • H2A/c
  • H2AFC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.87
transcription factor binding site profile
0.87
histone modification site profile
0.86
cellular component
0.78
transcription factor
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0C0S8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Deubiquitination
Reactome
HATs acetylate histones
Reactome
HDACs deacetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Deubiquitination
HATs acetylate histones
HDACs deacetylate histones
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (123)
1 – 10 of 123
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.99995994
p_ni: 0.00004006
Score: 0.716
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.991614679
p_ni: 0.008385321
Score: 0.777
Data Source: BioPlex,STRINGDB
XPC
Tbio
Novelty: 0.00775175
p_int: 0.988035389
p_ni: 0.011964611
Data Source: BioPlex
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.979069537
p_ni: 0.020930463
Data Source: BioPlex
H1FNT
Tdark
Novelty: 0.05593238
p_int: 0.97816216
p_ni: 0.021837839
Score: 0.202
Data Source: BioPlex,STRINGDB
APLF
Tbio
Novelty: 0.01347476
p_int: 0.975365393
p_ni: 0.024634606
p_wrong: 1e-9
Data Source: BioPlex
HIST1H4A
Tbio
Novelty: 0.00279614
p_int: 0.974190757
p_ni: 0.025809243
Score: 0.944
Data Source: BioPlex,STRINGDB
ZSCAN20
Tdark
Family: TF
Novelty: 0.37441538
p_int: 0.929142624
p_ni: 0.070857376
Data Source: BioPlex
HMGN4
Tdark
Novelty: 0.01498794
p_int: 0.922552333
p_ni: 0.077447667
Score: 0.163
Data Source: BioPlex,STRINGDB
DGKZ
Tbio
Family: Enzyme
Novelty: 0.01312044
p_int: 0.910979589
p_ni: 0.089020411
Data Source: BioPlex
Publication Statistics
PubMed Score  16.92

PubMed score by year
PubTator Score  2.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer