Protein Classes
Protein Summary
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of ...more
- ENST00000375177
- ENSP00000364321
- ENSG00000228454
- ENST00000411583
- ENSP00000407942
- ENSG00000228267
- ENST00000435363
- ENSP00000415941
- ENSG00000224389
- ENST00000435500
- ENSP00000412786
- ENSG00000233312
- ENST00000449788
- ENSP00000414200
- ENSG00000236625
- CO4
- CPAMD3
- CH
- C4F
- CO4
- C4B1
- C4B2
- C4B3
- C4B5
- C4BD
- C4B12
- C4B_2
- CPAMD3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein complex | 1 | ||
biological term | 0.82 | ||
small molecule perturbation | 0.81 | ||
cell line | 0.68 | ||
disease | 0.67 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1100.03 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 296 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1100.03 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 296 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (148)
Reactome (6)
KEGG (4)
WikiPathways (138)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of C3 and C5 | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of C3 and C5 | ||||
Complement cascade | ||||
Immune System | ||||
Initial triggering of complement | ||||
Innate Immune System | ||||
Gene Ontology Terms (22)
Functions (4)
Components (10)
Processes (8)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (189)
1 – 10 of 189
C4A
Novelty: 0.00075974
Score: 0.995
Data Source: Reactome,STRINGDB
CD46
Novelty: 0.00117011
Score: 0.992
Data Source: Reactome,STRINGDB
CR1
Novelty: 0.00116665
Score: 0.991
Data Source: Reactome,STRINGDB
MASP2
Family: Enzyme
Novelty: 0.00589925
Score: 0.986
Data Source: Reactome,STRINGDB
C1S
Novelty: 0.00094571
Score: 0.983
Data Source: Reactome,STRINGDB
CFB
Novelty: 0.00128742
Score: 0.982
Data Source: STRINGDB
C4BPA
Novelty: 0.00381157
Score: 0.977
Data Source: Reactome,STRINGDB
C1R
Novelty: 0.00294403
Score: 0.977
Data Source: Reactome,STRINGDB
C2
Novelty: 0.01346942
Score: 0.976
Data Source: Reactome,STRINGDB
MASP1
Family: Enzyme
Novelty: 0.00306091
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 1100.03
PubMed score by year
PubTator Score 737.47
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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