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Tbio
C4B
Complement C4-B

Protein Summary
Description
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375177
  • ENSP00000364321
  • ENSG00000228454
  • ENST00000411583
  • ENSP00000407942
  • ENSG00000228267
  • ENST00000435363
  • ENSP00000415941
  • ENSG00000224389
  • ENST00000435500
  • ENSP00000412786
  • ENSG00000233312
  • ENST00000449788
  • ENSP00000414200
  • ENSG00000236625

Symbol
  • CO4
  • CPAMD3
  • CH
  • C4F
  • CO4
  • C4B1
  • C4B2
  • C4B3
  • C4B5
  • C4BD
  • C4B12
  • C4B_2
  • CPAMD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
biological term
0.82
small molecule perturbation
0.81
cell line
0.68
disease
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1100.03   (req: < 5)
View Publications
Gene RIFs: 116   (req: <= 3)
View Gene RIFs
Antibodies: 296   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1100.03   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 296   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (148)
Activation of C3 and C5 (R-HSA-174577)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of C3 and C5
6 targets
R-HSA-174577
Reactome
Complement cascade
133 targets
R-HSA-166658
Reactome
Immune System
2246 targets
R-HSA-168256
Reactome
Initial triggering of complement
98 targets
R-HSA-166663
Reactome
Innate Immune System
1188 targets
R-HSA-168249
Name
Explore in Pharos
Explore in Source
Activation of C3 and C5
6 targets
R-HSA-174577
Complement cascade
133 targets
R-HSA-166658
Immune System
2246 targets
R-HSA-168256
Initial triggering of complement
98 targets
R-HSA-166663
Innate Immune System
1188 targets
R-HSA-168249
Protein-Protein Interactions (189)
1 – 10 of 189
C4A
Tbio
Novelty: 0.00075974
Score: 0.995
Data Source: Reactome,STRINGDB
CD46
Tbio
Novelty: 0.00117011
Score: 0.992
Data Source: Reactome,STRINGDB
CR1
Tbio
Novelty: 0.00116665
Score: 0.991
Data Source: Reactome,STRINGDB
MASP2
Tbio
Family: Enzyme
Novelty: 0.00589925
Score: 0.986
Data Source: Reactome,STRINGDB
C1S
Tchem
Novelty: 0.00094571
Score: 0.983
Data Source: Reactome,STRINGDB
CFB
Tchem
Novelty: 0.00128742
Score: 0.982
Data Source: STRINGDB
C4BPA
Tbio
Novelty: 0.00381157
Score: 0.977
Data Source: Reactome,STRINGDB
C1R
Tclin
Novelty: 0.00294403
Score: 0.977
Data Source: Reactome,STRINGDB
C2
Tbio
Novelty: 0.01346942
Score: 0.976
Data Source: Reactome,STRINGDB
MASP1
Tbio
Family: Enzyme
Novelty: 0.00306091
Score: 0.975
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1100.03

PubMed score by year
PubTator Score  737.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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