Protein Summary
Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of ...more
- ENST00000375177
- ENSP00000364321
- ENSG00000228454
- ENST00000411583
- ENSP00000407942
- ENSG00000228267
- ENST00000435363
- ENSP00000415941
- ENSG00000224389
- ENST00000435500
- ENSP00000412786
- ENSG00000233312
- ENST00000449788
- ENSP00000414200
- ENSG00000236625
- CO4
- CPAMD3
- CH
- C4F
- CO4
- C4B1
- C4B2
- C4B3
- C4B5
- C4BD
- C4B12
- C4B_2
- CPAMD3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein complex | 1 | ||
biological term | 0.82 | ||
small molecule perturbation | 0.81 | ||
cell line | 0.68 | ||
disease | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1541.33 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 296 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1541.33 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 296 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (189)
Nearest Tclin Targets
Pathways (148)
Reactome (6)
KEGG (4)
WikiPathways (138)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of C3 and C5 | ||||
Reactome | Complement cascade | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of C3 and C5 | ||||
Complement cascade | ||||
Immune System | ||||
Initial triggering of complement | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (4)
Components (10)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (284)
Items per page:
1 – 5 of 284
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
9 | 10 | 0 | 1.9 | 99.3 | ||||||
9 | 10 | 0 | 1.9 | 99.3 | ||||||
9 | 10 | 0 | 1.9 | 99.3 | ||||||
9 | 9 | 0 | 1.9 | 99.3 | ||||||
6 | 5 | 0 | 2.3 | 99 | ||||||
Items per page:
1 – 5 of 284
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.9 | 99.3 | |||||
0 | 1.9 | 99.3 | |||||
0 | 1.9 | 99.3 | |||||
0 | 1.9 | 99.3 | |||||
0 | 2.3 | 99 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88228 | 12268 | ||||||
Rat | RGD:9245878 | 103689965 | ||||||
Dog | complement C4-A | 481722 | ||||||
Horse | complement C4-A | 100059239 | ||||||
Cow | Bos taurus complement component 4A (C4A), mRNA. [Source:RefSeq mRNA;Acc:NM_001166485] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | complement C4-A | |||||
Horse | complement C4-A | |||||
Cow | Bos taurus complement component 4A (C4A), mRNA. [Source:RefSeq mRNA;Acc:NM_001166485] | |||||
Publication Statistics
PubMed Score 1541.33
PubMed score by year
PubTator Score 737.47
PubTator score by year
Related Publications
Text Mined References (172)
GeneRif Annotations (116)
Items per page:
0 of 0
PMID | Year | Title |
|---|