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Tdark
NUDT7
Peroxisomal coenzyme A diphosphatase NUDT7

Protein Summary
Description
Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternativel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268533
  • ENSP00000268533
  • ENSG00000140876
  • ENST00000437314
  • ENSP00000387707
  • ENST00000564085
  • ENSP00000457566
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
virus perturbation
0.99
histone modification site profile
0.86
molecular function
0.84
biological process
0.62


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 28   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 28   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 7
VGNC:5858
454256
Macaque
nudix hydrolase 7
715443
Mouse
MGI:1914778
67528
Rat
RGD:1306719
361413
Dog
nudix hydrolase 7
VGNC:44035
489703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nudix hydrolase 7
Macaque
nudix hydrolase 7
Mouse
Rat
Dog
nudix hydrolase 7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P0C024-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Peroxisomal lipid metabolism
Reactome
Peroxisomal protein import
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Peroxisomal lipid metabolism
Peroxisomal protein import
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (90)
1 – 10 of 90
NUDT19
Tdark
Novelty: 0.26928757
Score: 0.974
Data Source: STRINGDB
HMGCL
Tbio
Family: Enzyme
Novelty: 0.02741994
Score: 0.95
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.935
Data Source: STRINGDB
PAOX
Tchem
Family: Enzyme
Novelty: 0.00905719
Score: 0.926
Data Source: STRINGDB
GSTK1
Tchem
Family: Enzyme
Novelty: 0.04205366
Score: 0.923
Data Source: STRINGDB
ACOX2
Tbio
Family: Enzyme
Novelty: 0.02942359
Score: 0.923
Data Source: STRINGDB
EPHX2
Tchem
Family: Enzyme
Novelty: 0.00430741
Score: 0.923
Data Source: STRINGDB
TYSND1
Tbio
Family: Enzyme
Novelty: 0.16036122
Score: 0.92
Data Source: STRINGDB
HSD17B4
Tbio
Novelty: 0.00547499
Score: 0.916
Data Source: STRINGDB
BAAT
Tbio
Family: Enzyme
Novelty: 0.01336714
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.25

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer