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Tbio
ALDOC
Fructose-bisphosphate aldolase C

Protein Summary
Description
This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226253
  • ENSP00000226253
  • ENSG00000109107
  • ENST00000395321
  • ENSP00000378731

Symbol
  • ALDC
  • ALDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
small molecule perturbation
0.87
disease perturbation
0.83
interacting protein
0.83
disease
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.67   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 411   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.67   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aldolase, fructose-bisphosphate C
VGNC:9139
493951
Macaque
aldolase, fructose-bisphosphate C
709213
Mouse
MGI:101863
11676
Rat
RGD:2091
24191
Dog
aldolase, fructose-bisphosphate C
VGNC:37793
480622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aldolase, fructose-bisphosphate C
Macaque
aldolase, fructose-bisphosphate C
Mouse
Rat
Dog
aldolase, fructose-bisphosphate C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09972-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Glycolysis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Glycolysis
Immune System
Innate Immune System
Protein-Protein Interactions (182)
1 – 10 of 182
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00517474
p_int: 0.999998396
p_ni: 0.000001604
Score: 0.981
Data Source: BioPlex,STRINGDB
ALDOB
Tbio
Family: Enzyme
Novelty: 0.00856695
p_int: 0.999494531
p_ni: 0.000505469
Score: 0.806
Data Source: BioPlex,STRINGDB
TPI1
Tbio
Family: Enzyme
Novelty: 0.00074652
Score: 0.983
Data Source: STRINGDB
PFKP
Tbio
Family: Kinase
Novelty: 0.00808684
Score: 0.978
Data Source: STRINGDB
PFKL
Tbio
Family: Kinase
Novelty: 0.00586306
Score: 0.977
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.972
Data Source: STRINGDB
PFKM
Tbio
Family: Kinase
Novelty: 0.00217816
Score: 0.971
Data Source: STRINGDB
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
Score: 0.965
Data Source: STRINGDB
FBP2
Tbio
Family: Enzyme
Novelty: 0.00854851
Score: 0.961
Data Source: STRINGDB
FBP1
Tchem
Family: Enzyme
Novelty: 0.0029987
Score: 0.958
Data Source: STRINGDB
Publication Statistics
PubMed Score  55.67

PubMed score by year
PubTator Score  13.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer