Tbio ALDOC Fructose-bisphosphate aldolase C

Protein Summary

Description

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09972
• B2R5R3
• Q3SYL3
• Q6FH94
• Q6P0L5

Gene Name

• ALDOC

Ensembl ID

• ENST00000226253
• ENSP00000226253
• ENSG00000109107
• ENST00000395321
• ENSP00000378731

Symbol

• ALDC
• ALDC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.89
small molecule perturbation	0.87
disease perturbation	0.83
interacting protein	0.83
disease	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.74   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 411   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.74   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 411   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0