You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
FURIN
Furin

Protein Summary
Description
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268171
  • ENSP00000268171
  • ENSG00000140564
  • ENST00000610579
  • ENSP00000484952
  • ENST00000618099
  • ENSP00000483552

Symbol
  • FUR
  • PACE
  • PCSK3
  • FUR
  • PACE
  • SPC1
  • PCSK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.93
molecular function
0.91
cellular component
0.88
hub protein
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2335.33   (req: < 5)
Gene RIFs: 174   (req: <= 3)
Antibodies: 394   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2335.33   (req: >= 5)
Gene RIFs: 174   (req: > 3)
Antibodies: 394   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 289
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0