You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

Protein Summary
Description
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284440
  • ENSP00000284440
  • ENSG00000154277
  • ENST00000503431
  • ENSP00000422542

Symbol
  • NDGOA
  • PARK5
  • PGP95
  • SPG79
  • PGP9.5
  • Uch-L1
  • HEL-117
  • PGP 9.5
  • HEL-S-53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
hub protein
0.88
transcription factor perturbation
0.88
gene perturbation
0.85
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1853.4   (req: < 5)
Gene RIFs: 202   (req: <= 3)
Antibodies: 1966   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1853.4   (req: >= 5)
Gene RIFs: 202   (req: > 3)
Antibodies: 1966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (170)
UBC
Tbio
Novelty:  0.00204643
Score:  0.997
Data Source:  STRINGDB
UBA52
Tbio
Novelty:  0.01637744
Score:  0.996
Data Source:  STRINGDB
RPS27A
Tbio
Novelty:  0.00658124
Score:  0.995
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.991
Data Source:  STRINGDB
SNCA
Tchem
Novelty:  0.00012042
Score:  0.968
Data Source:  STRINGDB
UCHL3
Tchem
Family:  Enzyme
Novelty:  0.01206871
Score:  0.904
Data Source:  STRINGDB
COPS5
Tchem
Novelty:  0.00406225
Score:  0.853
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.848
Data Source:  STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.768
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.765
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (124)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ubiquitin C-terminal hydrolase L1
VGNC:1996
461185
Macaque
ubiquitin C-terminal hydrolase L1
701579
Mouse
MGI:103149
22223
Rat
RGD:3928
29545
Dog
ubiquitin C-terminal hydrolase L1 [Source:HGNC Symbol;Acc:HGNC:12513]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ubiquitin C-terminal hydrolase L1
Macaque
ubiquitin C-terminal hydrolase L1
Mouse
Rat
Dog
ubiquitin C-terminal hydrolase L1 [Source:HGNC Symbol;Acc:HGNC:12513]
Publication Statistics
PubMed Score 1853.40
PubMed score by year
PubTator Score 1107.05
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title