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Tchem
UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

Protein Summary
Description
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284440
  • ENSP00000284440
  • ENSG00000154277
  • ENST00000503431
  • ENSP00000422542

Symbol
  • NDGOA
  • PARK5
  • PGP95
  • SPG79
  • PGP9.5
  • Uch-L1
  • HEL-117
  • PGP 9.5
  • HEL-S-53
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
hub protein
0.88
transcription factor perturbation
0.88
gene perturbation
0.85
virus perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1452.3   (req: < 5)
Gene RIFs: 202   (req: <= 3)
Antibodies: 1966   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1452.3   (req: >= 5)
Gene RIFs: 202   (req: > 3)
Antibodies: 1966   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (124)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
UCH proteinases
Name
Explore in Pharos
Explore in Source
Deubiquitination
Metabolism of proteins
Post-translational protein modification
UCH proteinases
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (170)
1 – 10 of 170
UBC
Tbio
Novelty: 0.00161137
Score: 0.997
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01006012
Score: 0.996
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.01148413
Score: 0.995
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00895161
Score: 0.991
Data Source: STRINGDB
SNCA
Tchem
Novelty: 0.00021357
Score: 0.968
Data Source: STRINGDB
UCHL3
Tchem
Family: Enzyme
Novelty: 0.01675255
Score: 0.904
Data Source: STRINGDB
COPS5
Tbio
Novelty: 0.00481687
Score: 0.853
Data Source: STRINGDB
PRKN
Tbio
Family: Enzyme
Novelty: 0.00092228
Score: 0.848
Data Source: STRINGDB
HSPA8
Tchem
Novelty: 0.00100906
Score: 0.768
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.765
Data Source: STRINGDB
Publication Statistics
PubMed Score  1452.30

PubMed score by year
PubTator Score  1107.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEEL
1-70
KGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQ
70-140
AAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQG
140-210
EVRFSAVALCKAA
210-223
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA