Tbio CSF3 Granulocyte colony-stimulating factor

Protein Summary

Description

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P09919
• A8MXR7
• G-CSF

Gene Name

• CSF3

Ensembl ID

• ENST00000225474
• ENSP00000225474
• ENSG00000108342
• ENST00000394148
• ENSP00000377704
• ENST00000394149
• ENSP00000377705

Symbol

• C17orf33
• GCSF
• GCSF
• CSF3OS
• C17orf33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
biological term	0.94
gene perturbation	0.88
disease	0.86
cell type or tissue	0.77

Protein Classes

DTO Classes

Granulocyte Colony-stimulating Factor Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10692.88   (req: < 5)

Gene RIFs: 169   (req: <= 3)

Antibodies: 1146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10692.88   (req: >= 5)

Gene RIFs: 169   (req: > 3)

Antibodies: 1146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0