Tclin ALOX5 Arachidonate 5-lipoxygenase

Protein Summary

Description

Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Accession IDs

• P09917
• B7ZLS0
• E5FPY5
• E5FPY7
• E5FPY8
• Q5JQ14
• 5-LO

Gene Name

• ALOX5

Ensembl ID

• ENST00000374391
• ENSP00000363512
• ENSG00000012779
• ENST00000542434
• ENSP00000437634
• ENST00000610656
• ENSP00000484468
• ENSG00000275565
• ENST00000622021
• ENSP00000479958

Symbol

• LOG5
• 5-LO
• 5LPG
• LOG5
• 5-LOX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.99
protein domain	0.92
biological term	0.83
disease	0.82
PubMedID	0.79

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Arachidonate 5-lipoxygenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Arachidonate 5-lipoxygenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1927.17   (req: < 5)

Gene RIFs: 242   (req: <= 3)

Antibodies: 681   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1927.17   (req: >= 5)

Gene RIFs: 242   (req: > 3)

Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1264

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8