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Tclin
ALOX5
Arachidonate 5-lipoxygenase

Protein Summary
Description
Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374391
  • ENSP00000363512
  • ENSG00000012779
  • ENST00000542434
  • ENSP00000437634
  • ENST00000610656
  • ENSP00000484468
  • ENSG00000275565
  • ENST00000622021
  • ENSP00000479958

Symbol
  • LOG5
  • 5-LO
  • 5LPG
  • LOG5
  • 5-LOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
protein domain
0.92
biological term
0.83
disease
0.82
PubMedID
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1754.45   (req: < 5)
Gene RIFs: 204   (req: <= 3)
Antibodies: 681   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1754.45   (req: >= 5)
Gene RIFs: 204   (req: > 3)
Antibodies: 681   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 742
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
20
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
20
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arachidonate 5-lipoxygenase
VGNC:51965
450428
Macaque
arachidonate 5-lipoxygenase
707926
Mouse
MGI:87999
11689
Rat
RGD:2096
25290
Dog
arachidonate 5-lipoxygenase
VGNC:37813
477753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arachidonate 5-lipoxygenase
Macaque
arachidonate 5-lipoxygenase
Mouse
Rat
Dog
arachidonate 5-lipoxygenase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09917-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (43)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biosynthesis of D-series resolvins
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of DPA-derived SPMs
Reactome
Biosynthesis of DPAn-3 SPMs
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biosynthesis of D-series resolvins
Biosynthesis of DHA-derived SPMs
Biosynthesis of DPA-derived SPMs
Biosynthesis of DPAn-3 SPMs
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (181)
1 – 10 of 181
RUNDC1
Tdark
Novelty: 1.23644681
p_int: 0.999999979
p_ni: 1e-8
p_wrong: 1.1e-8
Score: 0.185
Data Source: BioPlex,STRINGDB
SLAIN1
Tdark
Novelty: 0.20438696
p_int: 0.999993014
p_ni: 0.000006986
Score: 0.175
Data Source: BioPlex,STRINGDB
TBC1D2B
Tdark
Novelty: 0.52348266
p_int: 0.999942066
p_ni: 0.000057934
Data Source: BioPlex
LSS
Tchem
Family: Enzyme
Novelty: 0.00735187
p_int: 0.999918519
p_ni: 0.000081474
p_wrong: 7e-9
Data Source: BioPlex
KDM3B
Tbio
Family: Epigenetic
Novelty: 0.05322289
p_int: 0.999916692
p_ni: 0.000083308
Data Source: BioPlex
TPP2
Tchem
Family: Enzyme
Novelty: 0.00803674
p_int: 0.999904353
p_ni: 0.000095647
Data Source: BioPlex
MPP5
Tbio
Novelty: 0.01707773
p_int: 0.999879806
p_ni: 0.000120194
Score: 0.189
Data Source: BioPlex,STRINGDB
NCSTN
Tbio
Novelty: 0.00453935
p_int: 0.999845316
p_ni: 0.000154684
Score: 0.334
Data Source: BioPlex,STRINGDB
OSBPL11
Tbio
Novelty: 0.17706694
p_int: 0.999779937
p_ni: 0.00022006
p_wrong: 3e-9
Data Source: BioPlex
CKAP5
Tbio
Novelty: 0.00623771
p_int: 0.999271159
p_ni: 0.000728841
Data Source: BioPlex
Publication Statistics
PubMed Score  1754.45

PubMed score by year
PubTator Score  2022.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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