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Tbio
IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

Protein Summary
Description
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371826
  • ENSP00000360891
  • ENSG00000119922
  • ENST00000638108
  • ENSP00000490935

Symbol
  • CIG-42
  • G10P2
  • IFI54
  • ISG54
  • P54
  • G10P2
  • IFI54
  • ISG54
  • cig42
  • IFI-54
  • IFIT-2
  • GARG-39
  • IFI-54K
  • ISG-54K
  • ISG-54 K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
1
transcription factor perturbation
0.98
PubMedID
0.74
small molecule perturbation
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.79   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.79   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0