You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IFIT2
Interferon-induced protein with tetratricopeptide repeats 2

Protein Summary
Description
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371826
  • ENSP00000360891
  • ENSG00000119922
  • ENST00000638108
  • ENSP00000490935

Symbol
  • CIG-42
  • G10P2
  • IFI54
  • ISG54
  • P54
  • G10P2
  • IFI54
  • ISG54
  • cig42
  • IFI-54
  • IFIT-2
  • GARG-39
  • IFI-54K
  • ISG-54K
  • ISG-54 K
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
virus perturbation
1
transcription factor perturbation
0.98
PubMedID
0.74
small molecule perturbation
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.79   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.79   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
4
4
95.1
9
3
4
1.1
92.3
3
3
0
1.1
88.7
neutrophil count
3
2
3
88.5
myeloid white cell count
1
1
1
75.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
95.1
4
1.1
92.3
0
1.1
88.7
neutrophil count
3
88.5
myeloid white cell count
1
75.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced protein with tetratricopeptide repeats 2
VGNC:4715
450585
Mouse
MGI:99449
15958
Rat
RGD:1307804
294091
Dog
interferon induced protein with tetratricopeptide repeats 2
VGNC:41877
479183
Cow
interferon induced protein with tetratricopeptide repeats 2
VGNC:30049
527528
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced protein with tetratricopeptide repeats 2
Mouse
Rat
Dog
interferon induced protein with tetratricopeptide repeats 2
Cow
interferon induced protein with tetratricopeptide repeats 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09913-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (182)
1 – 10 of 182
PHACTR4
Tbio
Family:  Enzyme
Novelty:  0.11366977
p_int:  1
Score:  0.825
Data Source:  BioPlex,STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
p_int:  0.999999809
p_ni:  1.91e-7
Score:  0.997
Data Source:  BioPlex,STRINGDB
HOMER3
Tbio
Novelty:  0.04408998
p_int:  0.999999606
p_ni:  3.94e-7
Score:  0.524
Data Source:  BioPlex,STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
p_int:  0.999999355
p_ni:  6.42e-7
p_wrong:  3e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
BATF3
Tbio
Family:  TF
Novelty:  0.01554987
p_int:  0.99723382
p_ni:  0.000001187
p_wrong:  0.002764993
Score:  0.291
Data Source:  BioPlex,STRINGDB
POLG2
Tbio
Family:  Enzyme
Novelty:  0.0233323
p_int:  0.99225022
p_ni:  0.00774978
Score:  0.823
Data Source:  BioPlex,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.929867778
p_ni:  0.070132222
Score:  0.174
Data Source:  BioPlex,STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.995
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.994
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.993
Data Source:  STRINGDB
Publication Statistics
PubMed Score  92.79

PubMed score by year
PubTator Score  143.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: