IFIT2
Interferon-induced protein with tetratricopeptide repeats 2
Protein Summary
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
- ENST00000371826
- ENSP00000360891
- ENSG00000119922
- ENST00000638108
- ENSP00000490935
- CIG-42
- G10P2
- IFI54
- ISG54
- P54
- G10P2
- IFI54
- ISG54
- cig42
- IFI-54
- IFIT-2
- GARG-39
- IFI-54K
- ISG-54K
- ISG-54 K
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
virus perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
PubMedID | 0.74 | ||
small molecule perturbation | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.79 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 192 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 112.79 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 192 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0