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Tbio
IFI6
Interferon alpha-inducible protein 6

Protein Summary
Description
Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells (PubMed:25757571). This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339145
  • ENSP00000342513
  • ENSG00000126709
  • ENST00000361157
  • ENSP00000354736
  • ENST00000362020
  • ENSP00000355152

Symbol
  • G1P3
  • 6-16
  • G1P3
  • FAM14C
  • IFI616
  • IFI-6-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.87
small molecule perturbation
0.83
cell type or tissue
0.76
histone modification site profile
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.61   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.61   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
44.2
1
1
0
1.1
15.8
sex hormone-binding globulin measurement
2
1
2
12.7
body mass index
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
44.2
0
1.1
15.8
sex hormone-binding globulin measurement
2
12.7
body mass index
1
1.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon alpha inducible protein 6
VGNC:8914
450178
Macaque
interferon alpha inducible protein 6
716339
Dog
interferon alpha inducible protein 6
VGNC:41875
478170
Horse
interferon alpha inducible protein 6
VGNC:18945
100070860
Cow
interferon alpha inducible protein 6
VGNC:30047
512913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon alpha inducible protein 6
Macaque
interferon alpha inducible protein 6
Dog
interferon alpha inducible protein 6
Horse
interferon alpha inducible protein 6
Cow
interferon alpha inducible protein 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P09912-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Protein-Protein Interactions (143)
1 – 10 of 143
ISG15
Tbio
Novelty:  0.00203781
Score:  0.995
Data Source:  STRINGDB
OAS1
Tbio
Family:  Enzyme
Novelty:  0.00532331
Score:  0.994
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.994
Data Source:  STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
Score:  0.993
Data Source:  STRINGDB
OAS3
Tbio
Family:  Enzyme
Novelty:  0.02422229
Score:  0.992
Data Source:  STRINGDB
IFIT3
Tbio
Novelty:  0.00568113
Score:  0.992
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.991
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.991
Data Source:  STRINGDB
IFI35
Tbio
Novelty:  0.04309126
Score:  0.989
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.989
Data Source:  STRINGDB
Publication Statistics
PubMed Score  41.61

PubMed score by year
PubTator Score  17.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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