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Tclin
POLA1
DNA polymerase alpha catalytic subunit

Protein Summary
Description
Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180, a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error, and therefore is not well suited for replicating long complexes. In the cytosol, responsible for a substantial proportio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379059
  • ENSP00000368349
  • ENSG00000101868

Symbol
  • POLA
  • NSX
  • POLA
  • p180
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.96
virus
0.89
histone modification site profile
0.85
virus perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.37   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.37   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
44
platelet count
1
1
1
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
44
platelet count
1
14.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase alpha 1, catalytic subunit
VGNC:8330
100611187
Macaque
DNA polymerase alpha 1, catalytic subunit
699763
Mouse
MGI:99660
18968
Rat
RGD:621816
85241
Dog
DNA polymerase alpha 1, catalytic subunit
VGNC:44771
480869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA polymerase alpha 1, catalytic subunit
Macaque
DNA polymerase alpha 1, catalytic subunit
Mouse
Rat
Dog
DNA polymerase alpha 1, catalytic subunit
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09884-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Activation of the pre-replicative complex (R-HSA-68962)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Replication
Name
Explore in Pharos
Explore in Source
Activation of the pre-replicative complex
Cell Cycle
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Replication
Gene Ontology Terms (34)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (317)
1 – 10 of 317
PRIM1
Tbio
Family: Enzyme
Novelty: 0.0530384
p_int: 0.999999195
p_ni: 8.05e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BTF3
Tbio
Novelty: 0.01198537
p_int: 0.996020688
p_ni: 0.003979312
Data Source: BioPlex
BTF3L4
Tdark
Novelty: 0.61724061
p_int: 0.963955944
p_ni: 0.036044056
p_wrong: 1e-9
Data Source: BioPlex
ISCA2
Tbio
Novelty: 0.02194373
p_int: 0.760895626
p_ni: 0.239104374
Data Source: BioPlex
POLE
Tclin
Family: Enzyme
Novelty: 0.00371129
Score: 0.999
Data Source: Reactome,STRINGDB
MCM2
Tbio
Novelty: 0.00276275
Score: 0.999
Data Source: STRINGDB
PRIM2
Tbio
Family: Enzyme
Novelty: 0.05145449
Score: 0.999
Data Source: Reactome,STRINGDB
MCM3
Tbio
Novelty: 0.00593382
Score: 0.999
Data Source: STRINGDB
POLA2
Tbio
Family: Enzyme
Novelty: 0.07371844
Score: 0.999
Data Source: Reactome,STRINGDB
POLD3
Tbio
Family: Enzyme
Novelty: 0.02646621
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  251.37

PubMed score by year
PubTator Score  1213.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer