You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
PARP1
Poly [ADP-ribose] polymerase 1

Protein Summary
Description
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:17177976, PubMed:18172500, PubMed:19344625, PubMed:19661379, PubMed:23230272). Mediates the poly(ADP-ribosyl)ation of APLF and CHFR (PubMed:17396150). Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production (PubMed:17177976). Required for PARP9 and DTX3L recruitment to DNA damage sites (PubMed:23230272). PARP1-dependent PARP9-DTX3L-mediated ubiquitinatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366794
  • ENSP00000355759
  • ENSG00000143799

Symbol
  • ADPRT
  • PPOL
  • PARP
  • PPOL
  • ADPRT
  • ARTD1
  • ADPRT1
  • PARP-1
  • ADPRT 1
  • pADPRT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
hub protein
1
interacting protein
1
biological process
0.99
disease perturbation
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3680.61   (req: < 5)
Gene RIFs: 682   (req: <= 3)
Antibodies: 1714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3680.61   (req: >= 5)
Gene RIFs: 682   (req: > 3)
Antibodies: 1714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 67
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2845
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4