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Tchem
C1S
Complement C1s subcomponent

Protein Summary
Description
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328916
  • ENSP00000328173
  • ENSG00000182326
  • ENST00000360817
  • ENSP00000354057
  • ENST00000406697
  • ENSP00000385035

Symbol
  • EDSPD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.76
PubMedID
0.67
small molecule perturbation
0.66
tissue
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2260.82   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 518   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2260.82   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 518   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 74
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
nafamostat
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
2
3
88.8
docosapentaenoic acid measurement
1
1
1
85.8
fatty acid measurement
1
1
1
85.8
linolenic acid measurement
1
1
1
85.8
arachidonic acid measurement
1
1
1
85.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
3
88.8
docosapentaenoic acid measurement
1
85.8
fatty acid measurement
1
85.8
linolenic acid measurement
1
85.8
arachidonic acid measurement
1
85.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C1s
VGNC:12853
451808
Macaque
complement C1s
714589
Rat
RGD:619983
192262
Dog
complement C1s
VGNC:38588
486714
Horse
complement C1s
VGNC:15946
100060261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C1s
Macaque
complement C1s
Rat
Dog
complement C1s
Horse
complement C1s
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Classical antibody-mediated complement activation (R-HSA-173623)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Classical antibody-mediated complement activation
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Classical antibody-mediated complement activation
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Protein-Protein Interactions (101)
1 – 10 of 101
C1R
Tclin
Novelty: 0.00210654
p_int: 0.999999446
p_ni: 3.03e-7
p_wrong: 2.51e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
CCDC6
Tbio
Novelty: 0.00702098
p_int: 0.999998208
p_ni: 0.000001792
Score: 0.752
Data Source: BioPlex,STRINGDB
PPP4R1
Tbio
Family: Enzyme
Novelty: 0.10822249
p_int: 0.999763697
p_ni: 0.000236294
p_wrong: 1e-8
Score: 0.847
Data Source: BioPlex,STRINGDB
SERPING1
Tbio
Family: Enzyme
Novelty: 0.00068448
Score: 0.994
Data Source: Reactome,STRINGDB
C4A
Tbio
Novelty: 0.00062793
Score: 0.983
Data Source: Reactome,STRINGDB
C4B
Tbio
Novelty: 0.00068357
Score: 0.983
Data Source: Reactome,STRINGDB
C1QB
Tbio
Novelty: 0.01476497
Score: 0.972
Data Source: Reactome,STRINGDB
C1QA
Tbio
Novelty: 0.00987917
Score: 0.971
Data Source: Reactome,STRINGDB
C1QC
Tbio
Novelty: 0.0286777
Score: 0.97
Data Source: Reactome,STRINGDB
CRP
Tbio
Novelty: 0.00001517
Score: 0.938
Data Source: STRINGDB
Publication Statistics
PubMed Score  2260.82

PubMed score by year
PubTator Score  488.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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