C1S
Complement C1s subcomponent
Protein Summary
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency. [provided by RefSeq, Mar 2009]
- ENST00000328916
- ENSP00000328173
- ENSG00000182326
- ENST00000360817
- ENSP00000354057
- ENST00000406697
- ENSP00000385035
- EDSPD2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
gene perturbation | 0.76 | ||
PubMedID | 0.67 | ||
small molecule perturbation | 0.66 | ||
tissue | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3791.93 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 518 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3791.93 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 518 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 79
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2