You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LCT
Lactase-phlorizin hydrolase

Protein Summary
Description
LPH splits lactose in the small intestine. The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase activity and lactase activity. Mutations in this gene are associated with congenital lactase deficiency. Polymorphisms in this gene are associated with lactase persistence, in which intestinal lactase activity persists at childhood levels into adulthood. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264162
  • ENSP00000264162
  • ENSG00000115850

Symbol
  • LPH
  • LAC
  • LPH
  • LPH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.77
disease
0.72
pathway
0.66
gene perturbation
0.62
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.1   (req: < 5)
Gene RIFs: 96   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 499.1   (req: >= 5)
Gene RIFs: 96   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
5
5
0
7.1
90.7
1,5 anhydroglucitol measurement
1
1
0
16.9
85.7
monocyte count
2
2
2
77
leukocyte count
3
3
4
68.8
neutrophil count
3
2
3
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
7.1
90.7
1,5 anhydroglucitol measurement
0
16.9
85.7
monocyte count
2
77
leukocyte count
4
68.8
neutrophil count
3
68.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactase
VGNC:1985
459633
Macaque
lactase
707761
Mouse
MGI:104576
226413
Rat
RGD:620823
116569
Dog
lactase
VGNC:42616
483898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactase
Macaque
lactase
Mouse
Rat
Dog
lactase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P09848-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary carbohydrate
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary carbohydrate
Disease
Diseases of carbohydrate metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (94)
1 – 10 of 94
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.96
Data Source:  STRINGDB
GALM
Tbio
Family:  Enzyme
Novelty:  0.01067063
Score:  0.951
Data Source:  STRINGDB
LALBA
Tbio
Family:  Enzyme
Novelty:  0.00037262
Score:  0.93
Data Source:  STRINGDB
GCK
Tchem
Family:  Kinase
Novelty:  0.00112778
Score:  0.92
Data Source:  STRINGDB
G6PC
Tchem
Family:  Enzyme
Novelty:  0.00088094
Score:  0.92
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.919
Data Source:  STRINGDB
G6PC3
Tbio
Family:  Enzyme
Novelty:  0.01754871
Score:  0.916
Data Source:  STRINGDB
G6PC2
Tbio
Family:  Enzyme
Novelty:  0.01361918
Score:  0.913
Data Source:  STRINGDB
GLA
Tclin
Family:  Enzyme
Novelty:  0.00075604
Score:  0.912
Data Source:  STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  499.10

PubMed score by year
PubTator Score  1503.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: