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Tchem
FGR
Tyrosine-protein kinase Fgr

Protein Summary
Description
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374003
  • ENSP00000363115
  • ENSG00000000938
  • ENST00000374004
  • ENSP00000363116
  • ENST00000374005
  • ENSP00000363117
  • ENST00000399173
  • ENSP00000382126

Symbol
  • SRC2
  • SRC2
  • c-fgr
  • c-src2
  • p55-Fgr
  • p58-Fgr
  • p55c-fgr
  • p58c-fgr
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.99
protein domain
0.99
PubMedID
0.91
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.77   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 513   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 514.77   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 513   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3