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Tchem
FGR
Tyrosine-protein kinase Fgr

Protein Summary
Description
Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374003
  • ENSP00000363115
  • ENSG00000000938
  • ENST00000374004
  • ENSP00000363116
  • ENST00000374005
  • ENSP00000363117
  • ENST00000399173
  • ENSP00000382126

Symbol
  • SRC2
  • SRC2
  • c-fgr
  • c-src2
  • p55-Fgr
  • p58-Fgr
  • p55c-fgr
  • p58c-fgr
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.99
protein domain
0.99
PubMedID
0.91
drug perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.74   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 513   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 346.74   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 513   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
dasatinib
chemical structure image
bosutinib
chemical structure image
ibrutinib
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
36.2
body mass index
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
36.2
body mass index
1
1.7
Pathways (95)
FCGR activation (R-HSA-2029481)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
FCGR activation
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
FCGR activation
Fcgamma receptor (FCGR) dependent phagocytosis
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (41)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (237)
1 – 10 of 237
YES1
Tclin
Family: Kinase
Novelty: 0.00534936
p_int: 0.999993247
p_ni: 3e-9
p_wrong: 0.00000675
Score: 0.981
Data Source: BioPlex,STRINGDB
CDK14
Tchem
Family: Kinase
Novelty: 0.02074169
p_int: 0.989239332
p_ni: 3.2e-7
p_wrong: 0.010760348
Score: 0.37
Data Source: BioPlex,STRINGDB
CDK18
Tchem
Family: Kinase
Novelty: 0.053383
p_int: 0.88100438
p_ni: 0.000012146
p_wrong: 0.118983473
Score: 0.296
Data Source: BioPlex,STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.986
Data Source: STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.98
Data Source: STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00114929
Score: 0.971
Data Source: STRINGDB
HCK
Tclin
Family: Kinase
Novelty: 0.00237485
Score: 0.971
Data Source: STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00058994
Score: 0.964
Data Source: STRINGDB
SLA
Tbio
Novelty: 0.01923631
Score: 0.956
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.955
Data Source: STRINGDB
Publication Statistics
PubMed Score  346.74

PubMed score by year
PubTator Score  151.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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