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Tclin
TACSTD2
Tumor-associated calcium signal transducer 2

Protein Summary
Description
May function as a growth factor receptor. This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371225
  • ENSP00000360269
  • ENSG00000184292

Symbol
  • GA733-1
  • M1S1
  • TROP2
  • EGP1
  • GP50
  • M1S1
  • EGP-1
  • TROP2
  • GA7331
  • GA733-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
gene perturbation
0.91
virus perturbation
0.85
transcription factor perturbation
0.74
cellular component
0.71


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.34   (req: < 5)
Gene RIFs: 89   (req: <= 3)
Antibodies: 546   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 376.34   (req: >= 5)
Gene RIFs: 89   (req: > 3)
Antibodies: 546   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tumor associated calcium signal transducer 2
456890
Macaque
tumor associated calcium signal transducer 2
716334
Mouse
MGI:1861606
56753
Rat
RGD:1359498
494343
Cow
tumor associated calcium signal transducer 2
VGNC:35563
539853
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tumor associated calcium signal transducer 2
Macaque
tumor associated calcium signal transducer 2
Mouse
Rat
Cow
tumor associated calcium signal transducer 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09758-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (48)
1 – 10 of 48
CYP8B1
Tchem
Family:  Enzyme
Novelty:  0.01243408
p_int:  0.999947778
p_ni:  0.000052209
p_wrong:  1.3e-8
Score:  0.689
Data Source:  BioPlex,STRINGDB
CLDN1
Tbio
Novelty:  0.00505039
Score:  0.775
Data Source:  STRINGDB
KRTAP5-2
Tdark
Novelty:  3.93025514
Score:  0.75
Data Source:  STRINGDB
CHST6
Tbio
Family:  Enzyme
Novelty:  0.01917947
Score:  0.73
Data Source:  STRINGDB
UBIAD1
Tbio
Family:  Enzyme
Novelty:  0.02238863
Score:  0.689
Data Source:  STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
Score:  0.645
Data Source:  STRINGDB
RAB13
Tbio
Family:  Enzyme
Novelty:  0.02465609
Score:  0.632
Data Source:  STRINGDB
CLDN7
Tbio
Novelty:  0.00722366
Score:  0.619
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.601
Data Source:  STRINGDB
CLDN4
Tbio
Novelty:  0.00227337
Score:  0.595
Data Source:  STRINGDB
Publication Statistics
PubMed Score  376.34

PubMed score by year
PubTator Score  312.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer