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Tclin
CD3G
T-cell surface glycoprotein CD3 gamma chain

Protein Summary
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface (PubMed:8187769). Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -z ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000532917
  • ENSP00000431445
  • ENSG00000160654

Symbol
  • T3G
  • T3G
  • IMD17
  • CD3-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
tissue sample
0.78
biological process
0.66
molecular function
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.62   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 224.62   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (43)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Costimulation by the CD28 family
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Costimulation by the CD28 family
Downstream TCR signaling
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (362)
1 – 10 of 362
CD3E
Tclin
Novelty: 0.00541492
Score: 0.994
Data Source: Reactome,STRINGDB
CD3D
Tclin
Novelty: 0.00372579
Score: 0.989
Data Source: Reactome,STRINGDB
CD247
Tbio
Novelty: 0.00275443
Score: 0.982
Data Source: Reactome,STRINGDB
ZAP70
Tchem
Family: Kinase
Novelty: 0.00136499
Score: 0.971
Data Source: Reactome,STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00040453
Score: 0.969
Data Source: Reactome,STRINGDB
ITK
Tclin
Family: Kinase
Novelty: 0.00113895
Score: 0.967
Data Source: STRINGDB
CD8B
Tbio
Novelty: 0.00571233
Score: 0.963
Data Source: Reactome,STRINGDB
CD8A
Tbio
Novelty: 0.00003113
Score: 0.961
Data Source: Reactome,STRINGDB
CD4
Tclin
Novelty: 0.00001541
Score: 0.958
Data Source: Reactome,STRINGDB
CBL
Tbio
Family: Enzyme
Novelty: 0.00118988
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  224.62

PubMed score by year
PubTator Score  93.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer