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Tbio
SCT
Secretin

Protein Summary
Description
Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach. This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000176195
  • ENSP00000176195
  • ENSG00000070031
  • ENST00000622382
  • ENSP00000483559
  • ENSG00000274473
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.61
chemical
0.58
cell line
0.54
biological term
0.47
transcription factor perturbation
0.47


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1262.42   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1262.42   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
7.7
1
1
0
1.1
7.7
1
1
0
1.1
7.7
1
1
0
1.1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
7.7
0
1.1
7.7
0
1.1
7.7
0
1.1
7.7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P09683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Protein-Protein Interactions (180)
1 – 10 of 180
SCTR
Tclin
Family: GPCR
Novelty: 0.01163942
Score: 0.992
Data Source: Reactome,STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.989
Data Source: STRINGDB
VIP
Tbio
Novelty: 0.00024946
Score: 0.989
Data Source: STRINGDB
VIPR1
Tchem
Family: GPCR
Novelty: 0.0016529
Score: 0.986
Data Source: STRINGDB
ADCYAP1
Tbio
Family: Enzyme
Novelty: 0.00080219
Score: 0.983
Data Source: STRINGDB
GIP
Tchem
Novelty: 0.0007219
Score: 0.976
Data Source: STRINGDB
GHRH
Tbio
Novelty: 0.00058152
Score: 0.975
Data Source: STRINGDB
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
Score: 0.973
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.966
Data Source: STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  1262.42

PubMed score by year
PubTator Score  988.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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