Tbio GIP Gastric inhibitory polypeptide

Protein Summary

Description

Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09681
• Q4VB42
• Q6NTD3
• GIP

Gene Name

• GIP

Ensembl ID

• ENST00000357424
• ENSP00000350005
• ENSG00000159224

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.82
cell type or tissue	0.75
biological term	0.69
cell line	0.59
PubMedID	0.58

Protein Classes

DTO Classes

Gastric Inhibitory Polypeptide Receptor / Gastric Inhibitory Polypeptide

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.35   (req: < 5)

Gene RIFs: 81   (req: <= 3)

Antibodies: 328   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.35   (req: >= 5)

Gene RIFs: 81   (req: > 3)

Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0