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Tchem
CTSH
Pro-cathepsin H

Protein Summary
Description
Important for the overall degradation of proteins in lysosomes. The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220166
  • ENSP00000220166
  • ENSG00000103811

Symbol
  • CPSB
  • ACC4
  • ACC5
  • CPSB
  • ACC-4
  • ACC-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
disease perturbation
0.97
biological process
0.96
gene perturbation
0.96
kinase perturbation
0.96


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.23   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 288.23   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
86.1
1
1
0
1.3
53.8
1
1
0
1.3
42.6
1
1
0
1.1
22.7
1
1
0
1.1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
86.1
0
1.3
53.8
0
1.3
42.6
0
1.1
22.7
0
1.1
13.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin H
VGNC:2480
740462
Macaque
cathepsin H
711437
Mouse
MGI:107285
13036
Rat
RGD:2447
25425
Dog
cathepsin H
VGNC:39713
479065
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin H
Macaque
cathepsin H
Mouse
Rat
Dog
cathepsin H
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09668-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MHC class II antigen presentation
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Innate Immune System
MHC class II antigen presentation
Metabolism of proteins
Gene Ontology Terms (48)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (141)
1 – 10 of 141
CSTA
Tbio
Novelty: 0.00453121
p_int: 0.999995747
p_ni: 0.000004253
Score: 0.776
Data Source: BioPlex,STRINGDB
CST5
Tbio
Novelty: 0.04273227
p_int: 0.999956686
p_ni: 0.000043314
Score: 0.473
Data Source: BioPlex,STRINGDB
CST1
Tbio
Novelty: 0.02399609
p_int: 0.999935913
p_ni: 0.000064087
Score: 0.348
Data Source: BioPlex,STRINGDB
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
p_int: 0.999821636
p_ni: 0.000178364
Score: 0.156
Data Source: BioPlex,STRINGDB
TEFM
Tbio
Novelty: 0.10836617
p_int: 0.999107668
p_ni: 0.000892202
p_wrong: 1.29e-7
Data Source: BioPlex
AIRE
Tbio
Family: TF; Epigenetic
Novelty: 0.00158659
p_int: 0.997741797
p_ni: 0.002255984
p_wrong: 0.000002219
Score: 0.214
Data Source: BioPlex,STRINGDB
SLCO6A1
Tbio
Family: Transporter
Novelty: 0.07836028
p_int: 0.994216162
p_ni: 0.005783828
p_wrong: 1e-8
Score: 0.184
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.991494752
p_ni: 0.008505243
p_wrong: 5e-9
Data Source: BioPlex
POC5
Tbio
Novelty: 0.09211907
p_int: 0.987421248
p_ni: 0.011560449
p_wrong: 0.001018302
Score: 0.179
Data Source: BioPlex,STRINGDB
TCTN3
Tdark
Novelty: 0.24504659
p_int: 0.986201301
p_ni: 0.011823769
p_wrong: 0.00197493
Score: 0.219
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  288.23

PubMed score by year
PubTator Score  119.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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