Tchem HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1

Protein Summary

Description

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection (PubMed:17371836). May bind to specific miRNA hairpins (PubMed:28431233). (Microbial infection) May play a role in HCV RNA replication. This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016]

Uniprot Accession IDs

• P09651
• A8K4Z8
• Q3MIB7
• Q6PJZ7
• hnRNP A1

Gene Name

• HNRNPA1

Ensembl ID

• ENST00000340913
• ENSP00000341826
• ENSG00000135486
• ENST00000546500
• ENSP00000448617
• ENST00000547276
• ENSP00000447260
• ENST00000547566
• ENSP00000449913

Symbol

• HNRPA1
• UP 1
• ALS19
• ALS20
• HNRPA1
• IBMPFD3
• HNRPA1L3
• hnRNP A1
• hnRNP-A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
transcription factor perturbation	0.97
co-expressed gene	0.91
transcription factor binding site profile	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.92   (req: < 5)

Gene RIFs: 178   (req: <= 3)

Antibodies: 452   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.92   (req: >= 5)

Gene RIFs: 178   (req: > 3)

Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0