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Tbio
DLD
Dihydrolipoyl dehydrogenase, mitochondrial

Protein Summary
Description
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205402
  • ENSP00000205402
  • ENSG00000091140
  • ENST00000417551
  • ENSP00000390667
  • ENST00000437604
  • ENSP00000387542

Symbol
  • GCSL
  • LAD
  • PHE3
  • E3
  • LAD
  • DLDD
  • DLDH
  • GCSL
  • PHE3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
virus perturbation
0.94
disease perturbation
0.93
protein domain
0.92
molecular function
0.86


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.94   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 460.94   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dihydrolipoamide dehydrogenase
VGNC:13647
463861
Macaque
dihydrolipoamide dehydrogenase
700494
Mouse
MGI:107450
13382
Rat
RGD:735073
298942
Dog
dihydrolipoamide dehydrogenase
VGNC:39976
403978
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dihydrolipoamide dehydrogenase
Macaque
dihydrolipoamide dehydrogenase
Mouse
Rat
Dog
dihydrolipoamide dehydrogenase
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Citric acid cycle (TCA cycle)
Reactome
Glycine degradation
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Lysine catabolism
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Citric acid cycle (TCA cycle)
Glycine degradation
Glyoxylate metabolism and glycine degradation
Lysine catabolism
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (247)
1 – 10 of 247
OGDHL
Tbio
Family: Enzyme
Novelty: 0.05079572
p_int: 1
Score: 0.987
Data Source: BioPlex,STRINGDB
PDHX
Tbio
Family: Enzyme
Novelty: 0.00946631
p_int: 0.999998313
p_ni: 0.000001687
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.999992693
p_ni: 0.000007305
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
MRPS36
Tdark
Novelty: 0.23031933
p_int: 0.999800686
p_ni: 0.000199314
Score: 0.649
Data Source: BioPlex,STRINGDB
SLX4IP
Tdark
Novelty: 0.25359409
p_int: 0.999761271
p_ni: 0.000238724
p_wrong: 5e-9
Score: 0.159
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999721753
p_ni: 0.000278247
Data Source: BioPlex
DLST
Tbio
Family: Enzyme
Novelty: 0.01516932
p_int: 0.999605395
p_ni: 0.000394605
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SIAH1
Tbio
Family: Enzyme
Novelty: 0.00831224
p_int: 0.999396481
p_ni: 0.000603519
Score: 0.59
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.998932939
p_ni: 0.001067061
Data Source: BioPlex
FMC1
Tbio
Novelty: 0.06702205
p_int: 0.998489121
p_ni: 0.000975379
p_wrong: 0.000535499
Score: 0.185
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  460.94

PubMed score by year
PubTator Score  535.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer