Tbio DLD Dihydrolipoyl dehydrogenase, mitochondrial

Protein Summary

Description

Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex) (PubMed:15712224, PubMed:16442803, PubMed:16770810, PubMed:17404228, PubMed:20160912, PubMed:20385101). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). In monomeric form may have additional moonlighting function as serine protease (PubMed:17404228). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. Mutations in this gene have been identified in patients with E3-deficient maple syrup urine disease and lipoamide dehydrogenase deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P09622
• B2R5X0
• B4DHG0
• B4DT69
• Q14131
• Q14167
• Q59EV8
• Q8WTS4

Gene Name

• DLD

Ensembl ID

• ENST00000205402
• ENSP00000205402
• ENSG00000091140
• ENST00000417551
• ENSP00000390667
• ENST00000437604
• ENSP00000387542

Symbol

• GCSL
• LAD
• PHE3
• E3
• LAD
• DLDD
• DLDH
• GCSL
• PHE3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99
virus perturbation	0.94
disease perturbation	0.93
protein domain	0.92
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Dihydrolipoyl Dehydrogenase, Mitochondrial

Protein / Oxidoreductase / Oxidase / Dihydrolipoyl Dehydrogenase, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Dihydrolipoyl Dehydrogenase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Dihydrolipoyl Dehydrogenase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.14   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 448   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.14   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0