You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HMOX1
Heme oxygenase 1

Protein Summary
Description
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216117
  • ENSP00000216117
  • ENSG00000100292

Symbol
  • HO
  • HO1
  • HO-1
  • HSP32
  • HMOX1D
  • bK286B10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
gene perturbation
1
transcription factor perturbation
1
small molecule perturbation
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8879.36   (req: < 5)
Gene RIFs: 880   (req: <= 3)
Antibodies: 979   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8879.36   (req: >= 5)
Gene RIFs: 880   (req: > 3)
Antibodies: 979   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (349)
ADAM33
Tchem
Family:  Enzyme
Novelty:  0.00584097
p_int:  0.999981762
p_ni:  0.000018238
Data Source:  BioPlex
LRRC27
Tdark
Novelty:  2.37640076
p_int:  0.999898242
p_ni:  0.000101758
Score:  0.169
Data Source:  BioPlex,STRINGDB
SRPRB
Tbio
Novelty:  0.04735362
p_int:  0.990219626
p_ni:  0.009780374
Data Source:  BioPlex
UGT8
Tbio
Family:  Enzyme
Novelty:  0.02518383
p_int:  0.988644688
p_ni:  0.011355312
Score:  0.207
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.958467773
p_ni:  0.041532227
Data Source:  BioPlex
HSD17B1
Tchem
Family:  Enzyme
Novelty:  0.00313425
p_int:  0.954601052
p_ni:  0.045398721
p_wrong:  2.26e-7
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.93771541
p_ni:  0.06228459
Data Source:  BioPlex
C5AR2
Tbio
Family:  GPCR
Novelty:  0.01193736
p_int:  0.917265742
p_ni:  0.082734258
Data Source:  BioPlex
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
p_int:  0.91663102
p_ni:  0.08336898
Score:  0.231
Data Source:  BioPlex,STRINGDB
TEX264
Tbio
Novelty:  0.32406417
p_int:  0.904592478
p_ni:  0.095407522
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Heme degradation
Reactome
Immune System
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Heme degradation
Immune System
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (69)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
51.7
BMI-adjusted hip circumference
1
1
1
44.2
1
1
1
30.2
low density lipoprotein cholesterol measurement
1
1
1
28.1
total cholesterol measurement
2
1
2
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
51.7
BMI-adjusted hip circumference
1
44.2
1
30.2
low density lipoprotein cholesterol measurement
1
28.1
total cholesterol measurement
2
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heme oxygenase 1
VGNC:5270
470195
Macaque
heme oxygenase 1
719266
Mouse
MGI:96163
15368
Rat
RGD:2806
24451
Dog
heme oxygenase 1
VGNC:41719
442987
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heme oxygenase 1
Macaque
heme oxygenase 1
Mouse
Rat
Dog
heme oxygenase 1
Publication Statistics
PubMed Score 8879.36
PubMed score by year
PubTator Score 3113.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title