Protein Summary
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq, Jul 2008]
- ENST00000216117
- ENSP00000216117
- ENSG00000100292
- HO
- HO1
- HO-1
- HSP32
- HMOX1D
- bK286B10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
gene perturbation | 1 | ||
transcription factor perturbation | 1 | ||
small molecule perturbation | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8879.36 (req: < 5)
Gene RIFs: 880 (req: <= 3)
Antibodies: 979 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8879.36 (req: >= 5)
Gene RIFs: 880 (req: > 3)
Antibodies: 979 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 60
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (349)
ADAM33
Family: Enzyme
Novelty: 0.00584097
p_int: 0.999981762
p_ni: 0.000018238
Data Source: BioPlex
LRRC27
Novelty: 2.37640076
p_int: 0.999898242
p_ni: 0.000101758
Score: 0.169
Data Source: BioPlex,STRINGDB
UGT8
Family: Enzyme
Novelty: 0.02518383
p_int: 0.988644688
p_ni: 0.011355312
Score: 0.207
Data Source: BioPlex,STRINGDB
CDK15
Family: Kinase
Novelty: 0.3870338
p_int: 0.958467773
p_ni: 0.041532227
Data Source: BioPlex
HSD17B1
Family: Enzyme
Novelty: 0.00313425
p_int: 0.954601052
p_ni: 0.045398721
p_wrong: 2.26e-7
Data Source: BioPlex
SLC39A8
Family: Transporter
Novelty: 0.00923197
p_int: 0.91663102
p_ni: 0.08336898
Score: 0.231
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (33)
Reactome (11)
KEGG (9)
PathwayCommons (3)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Heme degradation | ||||
Reactome | Immune System | ||||
Reactome | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Heme degradation | ||||
Immune System | ||||
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (69)
Functions (6)
Components (9)
Processes (54)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 1 | 1 | 1 | 51.7 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 44.2 | |||||
1 | 1 | 1 | 30.2 | ||||||
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 28.1 | |||||
total cholesterol measurement | 2 | 1 | 2 | 21.5 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 1 | 51.7 | |||||
BMI-adjusted hip circumference | 1 | 44.2 | |||||
1 | 30.2 | ||||||
low density lipoprotein cholesterol measurement | 1 | 28.1 | |||||
total cholesterol measurement | 2 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | heme oxygenase 1 | VGNC:5270 | 470195 | |||||
Macaque | heme oxygenase 1 | 719266 | ||||||
Mouse | MGI:96163 | 15368 | ||||||
Rat | RGD:2806 | 24451 | ||||||
Dog | heme oxygenase 1 | VGNC:41719 | 442987 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | heme oxygenase 1 | |||||
Macaque | heme oxygenase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | heme oxygenase 1 | |||||
Publication Statistics
PubMed Score 8879.36
PubMed score by year
PubTator Score 3113.42
PubTator score by year
Related Publications
Text Mined References (952)
GeneRif Annotations (880)
Items per page:
0 of 0
PMID | Year | Title |
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