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Tbio
WNT2
Protein Wnt-2

Protein Summary
Description
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265441
  • ENSP00000265441
  • ENSG00000105989

Symbol
  • INT1L1
  • IRP
  • IRP
  • INT1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
gene perturbation
0.75
PubMedID
0.71
tissue sample
0.68
pathway
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.76   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.76   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
1
2
92.5
waist-hip ratio
2
1
2
90.9
Dupuytren Contracture
1
1
0
1.2
32.6
tonsillectomy risk measurement
1
1
0
1
11.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
92.5
waist-hip ratio
2
90.9
Dupuytren Contracture
0
1.2
32.6
tonsillectomy risk measurement
0
1
11.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 2
VGNC:4565
463673
Mouse
MGI:98954
22413
Rat
RGD:621346
114487
Dog
Wnt family member 2
VGNC:48422
612141
Horse
Wnt family member 2
VGNC:25044
100056092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Wnt family member 2
Mouse
Rat
Dog
Wnt family member 2
Horse
Wnt family member 2
Pathways (61)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
Signaling by WNT
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Signaling by WNT
Gene Ontology Terms (36)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (240)
1 – 10 of 240
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.928615046
p_ni: 0.071384954
Score: 0.254
Data Source: BioPlex,STRINGDB
FZD4
Tchem
Family: GPCR
Novelty: 0.00577957
Score: 0.986
Data Source: STRINGDB
FZD1
Tbio
Family: GPCR
Novelty: 0.01097201
Score: 0.985
Data Source: STRINGDB
FZD9
Tbio
Family: GPCR
Novelty: 0.01414546
Score: 0.981
Data Source: STRINGDB
LRP6
Tbio
Novelty: 0.00305615
Score: 0.981
Data Source: STRINGDB
FZD2
Tbio
Family: GPCR
Novelty: 0.00774893
Score: 0.98
Data Source: STRINGDB
FZD5
Tbio
Family: GPCR
Novelty: 0.01673829
Score: 0.971
Data Source: STRINGDB
FZD8
Tbio
Family: GPCR
Novelty: 0.01613553
Score: 0.971
Data Source: STRINGDB
FZD6
Tbio
Family: GPCR
Novelty: 0.01425136
Score: 0.971
Data Source: STRINGDB
FZD7
Tbio
Family: GPCR
Novelty: 0.00916448
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  261.76

PubMed score by year
PubTator Score  323.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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