Protein Classes
Protein Summary
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000265441
- ENSP00000265441
- ENSG00000105989
- INT1L1
- IRP
- IRP
- INT1L1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.95 | ||
gene perturbation | 0.75 | ||
PubMedID | 0.71 | ||
tissue sample | 0.68 | ||
pathway | 0.62 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.76 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 247 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.76 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 247 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 1 | 2 | 92.5 | |||||
waist-hip ratio | 2 | 1 | 2 | 90.9 | |||||
Dupuytren Contracture | 1 | 1 | 0 | 1.2 | 32.6 | ||||
tonsillectomy risk measurement | 1 | 1 | 0 | 1 | 11.5 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 92.5 | |||||
waist-hip ratio | 2 | 90.9 | |||||
Dupuytren Contracture | 0 | 1.2 | 32.6 | ||||
tonsillectomy risk measurement | 0 | 1 | 11.5 | ||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Wnt family member 2 | VGNC:4565 | 463673 | |||||
Mouse | MGI:98954 | 22413 | ||||||
Rat | RGD:621346 | 114487 | ||||||
Dog | Wnt family member 2 | VGNC:48422 | 612141 | |||||
Horse | Wnt family member 2 | VGNC:25044 | 100056092 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Wnt family member 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | Wnt family member 2 | |||||
Horse | Wnt family member 2 | |||||
Pathways (61)
Reactome (6)
KEGG (13)
PathwayCommons (31)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 6
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Reactome | Signaling by WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Signaling by WNT | ||||
Gene Ontology Terms (36)
Functions (3)
Components (6)
Processes (27)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Protein-Protein Interactions (240)
1 – 10 of 240
HSPA5
Novelty: 0.00043424
p_int: 0.928615046
p_ni: 0.071384954
Score: 0.254
Data Source: BioPlex,STRINGDB
FZD4
Family: GPCR
Novelty: 0.00577957
Score: 0.986
Data Source: STRINGDB
FZD1
Family: GPCR
Novelty: 0.01097201
Score: 0.985
Data Source: STRINGDB
FZD9
Family: GPCR
Novelty: 0.01414546
Score: 0.981
Data Source: STRINGDB
LRP6
Novelty: 0.00305615
Score: 0.981
Data Source: STRINGDB
FZD2
Family: GPCR
Novelty: 0.00774893
Score: 0.98
Data Source: STRINGDB
FZD5
Family: GPCR
Novelty: 0.01673829
Score: 0.971
Data Source: STRINGDB
FZD8
Family: GPCR
Novelty: 0.01613553
Score: 0.971
Data Source: STRINGDB
FZD6
Family: GPCR
Novelty: 0.01425136
Score: 0.971
Data Source: STRINGDB
FZD7
Family: GPCR
Novelty: 0.00916448
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score 261.76
PubMed score by year
PubTator Score 323.19
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait