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Tbio
INHBB
Inhibin beta B chain

Protein Summary
Description
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295228
  • ENSP00000295228
  • ENSG00000163083
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
PubMedID
0.99
biological process
0.97
protein domain
0.85
small molecule perturbation
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.69   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 400   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.69   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 400   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
1
3
86.8
platelet count
1
1
1
84.2
platelet crit
1
1
1
58.4
intraocular pressure measurement
1
2
2
47.5
breast size
1
1
1
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
86.8
platelet count
1
84.2
platelet crit
1
58.4
intraocular pressure measurement
2
47.5
breast size
1
17.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inhibin subunit beta B
VGNC:10855
470524
Mouse
MGI:96571
16324
Rat
RGD:2913
25196
Dog
inhibin subunit beta B
VGNC:42022
483880
Horse
inhibin subunit beta B
VGNC:51463
100067535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inhibin subunit beta B
Mouse
Rat
Dog
inhibin subunit beta B
Horse
inhibin subunit beta B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P09529-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (96)
Antagonism of Activin by Follistatin (R-HSA-2473224)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antagonism of Activin by Follistatin
Reactome
Glycoprotein hormones
Reactome
Metabolism of proteins
Reactome
Peptide hormone biosynthesis
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Antagonism of Activin by Follistatin
Glycoprotein hormones
Metabolism of proteins
Peptide hormone biosynthesis
Peptide hormone metabolism
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (50)
1 – 10 of 50
ACVR1C
Tbio
Family:  Kinase
Novelty:  0.01675672
Score:  0.985
Data Source:  Reactome,STRINGDB
ACVR1B
Tchem
Family:  Kinase
Novelty:  0.00633595
Score:  0.979
Data Source:  Reactome,STRINGDB
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
Score:  0.979
Data Source:  Reactome,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.974
Data Source:  Reactome,STRINGDB
FST
Tbio
Novelty:  0.00085875
Score:  0.969
Data Source:  Reactome,STRINGDB
INHA
Tbio
Novelty:  0.00168407
Score:  0.954
Data Source:  Reactome,STRINGDB
FSTL3
Tbio
Novelty:  0.01238701
Score:  0.947
Data Source:  Reactome,STRINGDB
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
Score:  0.946
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.938
Data Source:  STRINGDB
FSHB
Tbio
Novelty:  0.00510815
Score:  0.938
Data Source:  STRINGDB
Publication Statistics
PubMed Score  63.69

PubMed score by year
PubTator Score  27.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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