Protein Summary
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]
- ENST00000394295
- ENSP00000377833
- ENSG00000196975
- ENST00000536030
- ENSP00000441931
- ANX4
- ANX4
- P32.5
- PIG28
- PP4-X
- ZAP36
- PAP-II
- HEL-S-274
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.99 | ||
transcription factor perturbation | 0.98 | ||
interacting protein | 0.96 | ||
small molecule perturbation | 0.94 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431.37 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 431.37 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (2)
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1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 64.3 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 45.4 | |||||
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 64.3 | |||||
C-reactive protein measurement | 1 | 45.4 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | annexin A4 | VGNC:17 | 459542 | |||||
Macaque | annexin A4 | 701433 | ||||||
Mouse | MGI:88030 | 11746 | ||||||
Rat | RGD:621171 | 79124 | ||||||
Dog | annexin A4 | VGNC:37941 | 606756 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | annexin A4 | |||||
Macaque | annexin A4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | annexin A4 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (2)
PathwayCommons (1)
WikiPathways (1)
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1 – 1 of 1
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: netpath | EGFR1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
EGFR1 | ||||
Gene Ontology Terms (25)
Functions (8)
Components (10)
Processes (7)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | AgBase | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (59)
1 – 10 of 59
SF3A3
Novelty: 0.03815499
p_int: 0.934882444
p_ni: 0.065117555
p_wrong: 1e-9
Score: 0.281
Data Source: BioPlex,STRINGDB
DYSF
Novelty: 0.00248634
Score: 0.738
Data Source: STRINGDB
TSG101
Novelty: 0.00211746
Score: 0.668
Data Source: STRINGDB
GP2
Novelty: 0.00126542
Score: 0.651
Data Source: STRINGDB
CD63
Novelty: 0.00072515
Score: 0.649
Data Source: STRINGDB
CD81
Novelty: 0.00111328
Score: 0.645
Data Source: STRINGDB
SNRNP27
Novelty: 0.0175187
Score: 0.638
Data Source: STRINGDB
CD9
Novelty: 0.00095308
Score: 0.634
Data Source: STRINGDB
AHNAK
Novelty: 0.01201996
Score: 0.632
Data Source: STRINGDB
FDPS
Family: Enzyme
Novelty: 0.00164195
Score: 0.621
Data Source: STRINGDB
Publication Statistics
PubMed Score 431.37
PubMed score by year
PubTator Score 105.04
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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