Tbio ANXA4 Annexin A4

Protein Summary

Description

Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• P09525
• B4DDF9
• Q96F33
• Q9BWK1

Gene Name

• ANXA4

Ensembl ID

• ENST00000394295
• ENSP00000377833
• ENSG00000196975
• ENST00000536030
• ENSP00000441931

Symbol

• ANX4
• ANX4
• P32.5
• PIG28
• PP4-X
• ZAP36
• PAP-II
• HEL-S-274

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.99
transcription factor perturbation	0.98
interacting protein	0.96
small molecule perturbation	0.94

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.86   (req: < 5)

Gene RIFs: 40   (req: <= 3)

Antibodies: 458   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 479.86   (req: >= 5)

Gene RIFs: 40   (req: > 3)

Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0