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Tbio
CLTA
Clathrin light chain A

Protein Summary
Description
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242285
  • ENSP00000242285
  • ENSG00000122705
  • ENST00000345519
  • ENSP00000242284
  • ENST00000396603
  • ENSP00000379848
  • ENST00000433436
  • ENSP00000401019
  • ENST00000470744
  • ENSP00000419746
  • ENST00000538225
  • ENSP00000442869
  • ENST00000540080
  • ENSP00000437508

Symbol
  • LCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
transcription factor perturbation
0.97
drug perturbation
0.96
virus perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.42   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.42   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (295)
CLTC
Tbio
Novelty:  0.00256674
Score:  0.997
Data Source:  Reactome,STRINGDB
CLTCL1
Tbio
Novelty:  0.05667807
Score:  0.995
Data Source:  Reactome,STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
Score:  0.985
Data Source:  STRINGDB
HIP1R
Tbio
Novelty:  0.02502713
Score:  0.98
Data Source:  STRINGDB
HIP1
Tbio
Novelty:  0.03790722
Score:  0.974
Data Source:  STRINGDB
PICALM
Tbio
Novelty:  0.00800832
Score:  0.974
Data Source:  STRINGDB
ITSN2
Tbio
Novelty:  0.03036854
Score:  0.973
Data Source:  STRINGDB
DNM2
Tchem
Novelty:  0.00265965
Score:  0.97
Data Source:  Reactome,STRINGDB
DNAJC6
Tbio
Family:  Enzyme
Novelty:  0.01359669
Score:  0.97
Data Source:  STRINGDB
ACTR2
Tchem
Novelty:  0.00731489
Score:  0.965
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (54)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Beta-catenin independent WNT signaling
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Beta-catenin independent WNT signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
FlyBase
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
0.8
schizophrenia
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
0.8
schizophrenia
1
0.8
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
clathrin light chain A
VGNC:8808
465093
Macaque
clathrin light chain A
693659
Mouse
MGI:894297
12757
Rat
RGD:70919
83800
Dog
clathrin light chain A
VGNC:39365
100856559
Species
Name
OMA
EggNOG
Inparanoid
Chimp
clathrin light chain A
Macaque
clathrin light chain A
Mouse
Rat
Dog
clathrin light chain A
Publication Statistics
PubMed Score 47.42
PubMed score by year
PubTator Score 38.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title