Tbio CLTA Clathrin light chain A

Protein Summary

Description

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582). Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. This gene encodes one of two clathrin light chain proteins which are believed to function as regulatory elements. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P09496
• A8K4W3
• B4DIN1
• F5H6N3
• Q2XPN5
• Q53XZ1
• Lca

Gene Name

• CLTA

Ensembl ID

• ENST00000242285
• ENSP00000242285
• ENSG00000122705
• ENST00000345519
• ENSP00000242284
• ENST00000396603
• ENSP00000379848
• ENST00000433436
• ENSP00000401019
• ENST00000470744
• ENSP00000419746
• ENST00000538225
• ENSP00000442869
• ENST00000540080
• ENSP00000437508

Symbol

• LCA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
transcription factor perturbation	0.97
drug perturbation	0.96
virus perturbation	0.9

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Clathrin Light Chain A

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Clathrin Light Chain A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.42   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 389   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.42   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0