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Tbio
TPM1
Tropomyosin alpha-1 chain

Protein Summary
Description
Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dep ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267996
  • ENSP00000267996
  • ENSG00000140416
  • ENST00000288398
  • ENSP00000288398
  • ENST00000334895
  • ENSP00000334624
  • ENST00000358278
  • ENSP00000351022
  • ENST00000403994
  • ENSP00000385107
  • ENST00000559397
  • ENSP00000452879
  • ENST00000559556
  • ENSP00000453941
  • ENST00000561266
  • ENSP00000453955

Symbol
  • C15orf13
  • TMSA
  • CMH3
  • TMSA
  • CMD1Y
  • LVNC9
  • C15orf13
  • HEL-S-265
  • HTM-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
PubMedID
0.93
interacting protein
0.85
kinase perturbation
0.84
small molecule perturbation
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390   (req: < 5)
Gene RIFs: 97   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 390   (req: >= 5)
Gene RIFs: 97   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
2
5
95.6
platelet count
3
3
3
2.4
95
high density lipoprotein cholesterol measurement
4
4
4
88.4
blood metabolite measurement
1
1
1
86.9
metabolite measurement
1
1
1
78
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
95.6
platelet count
3
2.4
95
high density lipoprotein cholesterol measurement
4
88.4
blood metabolite measurement
1
86.9
metabolite measurement
1
78
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tropomyosin 1
VGNC:14837
453495
Mouse
MGI:98809
22003
Rat
RGD:3898
24851
Pig
tropomyosin 1
100037999
Chicken
tropomyosin 1 (alpha)
CGNC:49772
396366
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tropomyosin 1
Mouse
Rat
Pig
tropomyosin 1
Chicken
tropomyosin 1 (alpha)
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09493-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Striated Muscle Contraction
Gene Ontology Terms (38)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (198)
1 – 10 of 198
TPM2
Tbio
Novelty:  0.00406572
p_int:  0.999999996
p_ni:  4e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
KLHL21
Tbio
Novelty:  0.20694121
p_int:  0.999987986
p_ni:  0.000012008
p_wrong:  6e-9
Score:  0.213
Data Source:  BioPlex,STRINGDB
KXD1
Tdark
Novelty:  0.32146379
p_int:  0.999984834
p_ni:  0.000014383
p_wrong:  7.83e-7
Score:  0.768
Data Source:  BioPlex,STRINGDB
EXOC4
Tbio
Novelty:  0.01636648
p_int:  0.999884817
p_ni:  0.000115183
Score:  0.276
Data Source:  BioPlex,STRINGDB
DLG5
Tbio
Novelty:  0.01630244
p_int:  0.999377534
p_ni:  0.000050854
p_wrong:  0.000571612
Score:  0.353
Data Source:  BioPlex,STRINGDB
RUFY2
Tbio
Novelty:  0.50188929
p_int:  0.998963136
p_ni:  0.001036864
Score:  0.213
Data Source:  BioPlex,STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
p_int:  0.998773183
p_ni:  0.001216397
p_wrong:  0.00001042
Score:  0.213
Data Source:  BioPlex,STRINGDB
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.998700256
p_ni:  0.001299744
Data Source:  BioPlex
MAD1L1
Tbio
Novelty:  0.03550138
p_int:  0.996832336
p_ni:  0.003167664
Score:  0.332
Data Source:  BioPlex,STRINGDB
CROCC
Tbio
Novelty:  0.03718561
p_int:  0.991825333
p_ni:  0.008174666
Score:  0.213
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  390.00

PubMed score by year
PubTator Score  217.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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