Tbio TPM1 Tropomyosin alpha-1 chain

Protein Summary

Description

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09493
• B7Z5T7
• D9YZV2
• D9YZV3
• D9YZV8
• P09494
• P10469
• Q6DV89
• Q6DV90
• Q7Z6L8
• Q86W64
• Q96IK2
• Q9UCI1
• Q9UCI2
• Q9UCY9
• Q9Y427

Gene Name

• TPM1

Ensembl ID

• ENST00000267996
• ENSP00000267996
• ENSG00000140416
• ENST00000288398
• ENSP00000288398
• ENST00000334895
• ENSP00000334624
• ENST00000358278
• ENSP00000351022
• ENST00000403994
• ENSP00000385107
• ENST00000559397
• ENSP00000452879
• ENST00000559556
• ENSP00000453941
• ENST00000561266
• ENSP00000453955

Symbol

• C15orf13
• TMSA
• CMH3
• TMSA
• CMD1Y
• LVNC9
• C15orf13
• HEL-S-265
• HTM-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
PubMedID	0.93
interacting protein	0.85
kinase perturbation	0.84
small molecule perturbation	0.82

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Tropomyosin Alpha-1 Chain

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Actin Binding Motor Protein / Tropomyosin Alpha-1 Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.56   (req: < 5)

Gene RIFs: 122   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.56   (req: >= 5)

Gene RIFs: 122   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0