Protein Classes
Protein Summary
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
- ENST00000231061
- ENSP00000231061
- ENSG00000113140
- ON
- ON
- OI17
- BM-40
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
biological term | 0.97 | ||
PubMedID | 0.95 | ||
disease perturbation | 0.93 | ||
protein domain | 0.92 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1364.26 (req: < 5)
Gene RIFs: 231 (req: <= 3)
Antibodies: 716 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1364.26 (req: >= 5)
Gene RIFs: 231 (req: > 3)
Antibodies: 716 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 70.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 70.4 | |||||
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | secreted protein acidic and cysteine rich | VGNC:7154 | 471709 | |||||
Macaque | secreted protein acidic and cysteine rich | 712388 | ||||||
Mouse | MGI:98373 | 20692 | ||||||
Rat | RGD:3742 | 24791 | ||||||
Dog | secreted protein acidic and cysteine rich | VGNC:46701 | 100855736 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | secreted protein acidic and cysteine rich | |||||
Macaque | secreted protein acidic and cysteine rich | |||||
Mouse | ||||||
Rat | ||||||
Dog | secreted protein acidic and cysteine rich | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (13)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Reactome | Nuclear signaling by ERBB4 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Nuclear signaling by ERBB4 | ||||
Gene Ontology Terms (43)
Functions (4)
Components (12)
Processes (27)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (225)
1 – 10 of 225
COL1A2
Novelty: 0.00048334
Score: 0.992
Data Source: STRINGDB
COL1A1
Novelty: 0.00063584
Score: 0.986
Data Source: STRINGDB
FN1
Novelty: 0.00003647
Score: 0.982
Data Source: STRINGDB
THBS1
Novelty: 0.00073905
Score: 0.97
Data Source: STRINGDB
VEGFA
Novelty: 0.0000378
Score: 0.968
Data Source: STRINGDB
TGFB1
Novelty: 0.0001299
Score: 0.963
Data Source: STRINGDB
PLG
Family: Enzyme
Novelty: 0.00004806
Score: 0.954
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.95
Data Source: STRINGDB
PDGFB
Novelty: 0.00080876
Score: 0.95
Data Source: STRINGDB
TIMP1
Family: Enzyme
Novelty: 0.00020986
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score 1364.26
PubMed score by year
PubTator Score 698.26
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword