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Tbio
SPARC
SPARC

Protein Summary
Description
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231061
  • ENSP00000231061
  • ENSG00000113140

Symbol
  • ON
  • ON
  • OI17
  • BM-40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
biological term
0.97
PubMedID
0.95
disease perturbation
0.93
protein domain
0.92


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1364.26   (req: < 5)
Gene RIFs: 231   (req: <= 3)
Antibodies: 716   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1364.26   (req: >= 5)
Gene RIFs: 231   (req: > 3)
Antibodies: 716   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
70.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
secreted protein acidic and cysteine rich
VGNC:7154
471709
Macaque
secreted protein acidic and cysteine rich
712388
Mouse
MGI:98373
20692
Rat
RGD:3742
24791
Dog
secreted protein acidic and cysteine rich
VGNC:46701
100855736
Species
Name
OMA
EggNOG
Inparanoid
Chimp
secreted protein acidic and cysteine rich
Macaque
secreted protein acidic and cysteine rich
Mouse
Rat
Dog
secreted protein acidic and cysteine rich
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09486-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Nuclear signaling by ERBB4
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
ECM proteoglycans
Extracellular matrix organization
Hemostasis
Nuclear signaling by ERBB4
Protein-Protein Interactions (225)
1 – 10 of 225
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.992
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.986
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.982
Data Source: STRINGDB
THBS1
Tbio
Novelty: 0.00073905
Score: 0.97
Data Source: STRINGDB
VEGFA
Tclin
Novelty: 0.0000378
Score: 0.968
Data Source: STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
Score: 0.963
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.954
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.95
Data Source: STRINGDB
PDGFB
Tchem
Novelty: 0.00080876
Score: 0.95
Data Source: STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  1364.26

PubMed score by year
PubTator Score  698.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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