Protein Summary
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]
- ENST00000231061
- ENSP00000231061
- ENSG00000113140
- ON
- ON
- OI17
- BM-40
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.99 | ||
biological term | 0.97 | ||
PubMedID | 0.95 | ||
disease perturbation | 0.93 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1387.41 (req: < 5)
Gene RIFs: 231 (req: <= 3)
Antibodies: 716 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1387.41 (req: >= 5)
Gene RIFs: 231 (req: > 3)
Antibodies: 716 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (225)
Nearest Tclin Targets
Pathways (17)
Reactome (13)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Binding and Uptake of Ligands by Scavenger Receptors | ||||
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Reactome | Nuclear signaling by ERBB4 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Binding and Uptake of Ligands by Scavenger Receptors | ||||
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Nuclear signaling by ERBB4 | ||||
Viral Interactions (0)
Gene Ontology Terms (43)
Functions (4)
Components (12)
Processes (27)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 48.5 | |||||
red blood cell distribution width | 1 | 1 | 1 | 42.3 | |||||
systolic blood pressure change measurement | 1 | 1 | 1 | 24.5 | |||||
creatinine measurement | 1 | 1 | 1 | 8 | |||||
glomerular filtration rate | 1 | 1 | 1 | 3.9 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 48.5 | |||||
red blood cell distribution width | 1 | 42.3 | |||||
systolic blood pressure change measurement | 1 | 24.5 | |||||
creatinine measurement | 1 | 8 | |||||
glomerular filtration rate | 1 | 3.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | secreted protein acidic and cysteine rich | VGNC:7154 | 471709 | |||||
Macaque | secreted protein acidic and cysteine rich | 712388 | ||||||
Mouse | MGI:98373 | 20692 | ||||||
Rat | RGD:3742 | 24791 | ||||||
Dog | secreted protein acidic and cysteine rich | VGNC:46701 | 100855736 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | secreted protein acidic and cysteine rich | |||||
Macaque | secreted protein acidic and cysteine rich | |||||
Mouse | ||||||
Rat | ||||||
Dog | secreted protein acidic and cysteine rich | |||||
Publication Statistics
PubMed Score 1387.41
PubMed score by year
PubTator Score 698.26
PubTator score by year
Related Publications
Text Mined References (291)
GeneRif Annotations (231)
Items per page:
0 of 0
PMID | Year | Title |
|---|