GNAO1
Guanine nucleotide-binding protein G(o) subunit alpha
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
disease perturbation | 0.97 | ||
interacting protein | 0.77 | ||
microRNA | 0.74 | ||
PubMedID | 0.74 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Chaperonin-mediated protein folding | ||||
Reactome | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | ||||
Reactome | G alpha (i) signalling events | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Chaperonin-mediated protein folding | ||||
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding | ||||
G alpha (i) signalling events | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 2 | 4 | 4 | 92.4 | |||||
chronotype measurement | 2 | 3 | 2 | 1 | 88.8 | ||||
apolipoprotein A 1 measurement | 2 | 4 | 4 | 82.5 | |||||
depressive symptom measurement | 2 | 2 | 2 | 60.1 | |||||
neuroticism measurement | 2 | 2 | 2 | 60.1 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 4 | 92.4 | |||||
chronotype measurement | 2 | 1 | 88.8 | ||||
apolipoprotein A 1 measurement | 4 | 82.5 | |||||
depressive symptom measurement | 2 | 60.1 | |||||
neuroticism measurement | 2 | 60.1 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | G protein subunit alpha o1 | VGNC:13710 | 450173 | |||||
Macaque | G protein subunit alpha o1 | 574394 | ||||||
Mouse | MGI:95775 | 14681 | ||||||
Rat | RGD:628732 | 50664 | ||||||
Dog | G protein subunit alpha o1 | VGNC:41305 | 609157 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | G protein subunit alpha o1 | |||||
Macaque | G protein subunit alpha o1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein subunit alpha o1 | |||||
PMID | Year | Title |
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