Tbio GNAO1 Guanine nucleotide-binding protein G(o) subunit alpha

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Accession IDs

• P09471
• P29777
• Q8TD72
• Q9UMV4

Gene Name

• GNAO1

Ensembl ID

• ENST00000262493
• ENSP00000262493
• ENSG00000087258
• ENST00000262494
• ENSP00000262494
• ENST00000638705
• ENSP00000491223

Symbol

• GNAO
• NEDIM
• EIEE17
• HLA-DQB1
• G-ALPHA-o

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
disease perturbation	0.97
interacting protein	0.77
microRNA	0.74
PubMedID	0.74

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(o) Subunit Alpha

DTO Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Guanine Nucleotide-binding Protein G(o) Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.18   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 239   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 342.18   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (324)

Explore Interacting Targets

1 – 10 of 324

• See Interactions on String-DB

GNAI1

Tbio

Novelty:  0.0488971

p_int:  0.999999979

p_ni:  2e-8

Score:  0.957

Data Source:  BioPlex,STRINGDB

GNAI3

Tbio

Novelty:  0.03484857

p_int:  0.999999749

p_ni:  2.5e-7

Score:  0.938

Data Source:  BioPlex,STRINGDB

GNAI2

Tchem

Novelty:  0.03014729

p_int:  0.999999531

p_ni:  4.63e-7

p_wrong:  6e-9

Score:  0.952

Data Source:  BioPlex,STRINGDB

GNG3

Tbio

Novelty:  0.16941216

p_int:  0.999979135

p_ni:  0.000020865

Score:  0.993

Data Source:  BioPlex,STRINGDB

GNG2

Tbio

Novelty:  0.04807242

p_int:  0.998302339

p_ni:  0.001697661

Score:  0.99

Data Source:  BioPlex,Reactome,STRINGDB

RIC8A

Tbio

Novelty:  0.01846696

p_int:  0.997792235

p_ni:  0.002203926

p_wrong:  0.000003839

Score:  0.784

Data Source:  BioPlex,STRINGDB

NUFIP1

Tbio

Novelty:  0.11726869

p_int:  0.974642241

p_ni:  0.025357759

Data Source:  BioPlex

PI4K2A

Tbio

Family:  Kinase

Novelty:  0.03506675

p_int:  0.943177172

p_ni:  0.056822822

p_wrong:  6e-9

Data Source:  BioPlex

GJB7

Tbio

Novelty:  0.12555147

p_int:  0.93556089

p_ni:  0.064439105

p_wrong:  5e-9

Data Source:  BioPlex

FBXL22

Tdark

Novelty:  0.59436124

p_int:  0.931404592

p_ni:  0.068595408

Data Source:  BioPlex

Nearest Tclin Targets (23)

Explore Nearest Tclin Targets

Upstream (15)

Downstream (8)

1 – 5 of 15

EDNRB

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  2

1: Relaxin signaling pathway

2: Melanogenesis

OXTR

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  1

1: Oxytocin signaling pathway

CNR1

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  2

1: Retrograde endocannabinoid signaling

2: Rap1 signaling pathway

GABBR1

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  3

1: GABAergic synapse

2: Estrogen signaling pathway

3: Morphine addiction

GABBR2

Tclin

Family:  GPCR

KEGG Distance:  1

Common Pathways:  3

1: GABAergic synapse

2: Estrogen signaling pathway

3: Morphine addiction

Pathways (64)

Reactome (15)

KEGG (19)

PathwayCommons (25)

WikiPathways (5)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42 targets	R-HSA-6814122
Reactome	G alpha (i) signalling events	408 targets	R-HSA-418594

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42 targets	R-HSA-6814122
G alpha (i) signalling events	408 targets	R-HSA-418594

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (30)

Functions (9)

Components (5)

Processes (16)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
corticotropin-releasing hormone receptor 1 binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled serotonin receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G-protein beta/gamma-subunit complex binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
mu-type opioid receptor binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTP binding	Traceable Author Statement (TAS)	Reactome
GTPase activating protein binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (24)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 24

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	2	3	2	1	92.7
high density lipoprotein cholesterol measurement	EFO_0004612	6	5	8		84.8
apolipoprotein A 1 measurement	EFO_0004614	2	4	4		73.4
neuroticism measurement	EFO_0007660	2	2	2		72
depressive symptom measurement	EFO_0007006	2	2	2		67.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 24

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	2	1	92.7
high density lipoprotein cholesterol measurement	EFO_0004612	8		84.8
apolipoprotein A 1 measurement	EFO_0004614	4		73.4
neuroticism measurement	EFO_0007660	2		72
depressive symptom measurement	EFO_0007006	2		67.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ADP-ribosylation
Alternative splicing
Cell membrane
Complete proteome
Disease mutation
Epilepsy
GTP-binding
Lipoprotein
Magnesium

GWAS Trait Find Similar Targets

No Header	No Header
aortic measurement
apolipoprotein A 1 measurement
body mass index
cardioembolic stroke
cholesterol:total lipids ratio
cholesteryl esters:total lipids ratio
chronotype measurement
cognitive function measurement
daytime rest measurement
depressive symptom measurement

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging
nervous system phenotype
reproductive system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	G protein subunit alpha o1	VGNC:13710	450173
Macaque	G protein subunit alpha o1		574394
Mouse	guanine nucleotide binding protein, alpha O	MGI:95775	14681
Rat	G protein subunit alpha o1	RGD:628732	50664
Dog	G protein subunit alpha o1	VGNC:41305	609157

Species	Name	OMA	EggNOG	Inparanoid
Chimp	G protein subunit alpha o1
Macaque	G protein subunit alpha o1
Mouse	guanine nucleotide binding protein, alpha O
Rat	G protein subunit alpha o1
Dog	G protein subunit alpha o1

Publication Statistics

PubMed Score 342.18

PubMed score by year

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PubTator Score 99.22

PubTator score by year

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Related Publications

Text Mined References (78)

GeneRif Annotations (25)

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PMID	Year	Title