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Tbio
GNAO1
Guanine nucleotide-binding protein G(o) subunit alpha

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262493
  • ENSP00000262493
  • ENSG00000087258
  • ENST00000262494
  • ENSP00000262494
  • ENST00000638705
  • ENSP00000491223

Symbol
  • GNAO
  • NEDIM
  • EIEE17
  • HLA-DQB1
  • G-ALPHA-o
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.97
interacting protein
0.77
microRNA
0.74
PubMedID
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.05   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 313.05   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
4
4
92.4
chronotype measurement
2
3
2
1
88.8
apolipoprotein A 1 measurement
2
4
4
82.5
depressive symptom measurement
2
2
2
60.1
neuroticism measurement
2
2
2
60.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
92.4
chronotype measurement
2
1
88.8
apolipoprotein A 1 measurement
4
82.5
depressive symptom measurement
2
60.1
neuroticism measurement
2
60.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha o1
VGNC:13710
450173
Macaque
G protein subunit alpha o1
574394
Mouse
MGI:95775
14681
Rat
RGD:628732
50664
Dog
G protein subunit alpha o1
VGNC:41305
609157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit alpha o1
Macaque
G protein subunit alpha o1
Mouse
Rat
Dog
G protein subunit alpha o1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09471-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (64)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Ca2+ pathway
Chaperonin-mediated protein folding
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G alpha (i) signalling events
Gene Ontology Terms (30)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (324)
1 – 10 of 324
GNAI1
Tbio
Novelty:  0.0488971
p_int:  0.999999979
p_ni:  2e-8
Score:  0.957
Data Source:  BioPlex,STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999999749
p_ni:  2.5e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.999999531
p_ni:  4.63e-7
p_wrong:  6e-9
Score:  0.952
Data Source:  BioPlex,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
p_int:  0.999979135
p_ni:  0.000020865
Score:  0.993
Data Source:  BioPlex,STRINGDB
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.998302339
p_ni:  0.001697661
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
p_int:  0.997792235
p_ni:  0.002203926
p_wrong:  0.000003839
Score:  0.784
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.974642241
p_ni:  0.025357759
Data Source:  BioPlex
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.943177172
p_ni:  0.056822822
p_wrong:  6e-9
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.93556089
p_ni:  0.064439105
p_wrong:  5e-9
Data Source:  BioPlex
FBXL22
Tdark
Novelty:  0.59436124
p_int:  0.931404592
p_ni:  0.068595408
Data Source:  BioPlex
Publication Statistics
PubMed Score  313.05

PubMed score by year
PubTator Score  99.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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