GNAO1
Guanine nucleotide-binding protein G(o) subunit alpha
Protein Summary
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14. The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000262493
- ENSP00000262493
- ENSG00000087258
- ENST00000262494
- ENSP00000262494
- ENST00000638705
- ENSP00000491223
- GNAO
- NEDIM
- EIEE17
- HLA-DQB1
- G-ALPHA-o
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 1 | ||
disease perturbation | 0.97 | ||
interacting protein | 0.77 | ||
microRNA | 0.74 | ||
PubMedID | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 342.18 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 239 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 342.18 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 239 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0