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Tchem
FBP1
Fructose-1,6-bisphosphatase 1

Protein Summary
Description
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375326
  • ENSP00000364475
  • ENSG00000165140
  • ENST00000415431
  • ENSP00000408025

Symbol
  • FBP
  • FBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
molecular function
0.96
gene perturbation
0.85
transcription factor perturbation
0.8
biological process
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.95   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.95   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 240
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
snoring measurement
3
2
2
1
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
snoring measurement
2
1
70.9
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fructose-bisphosphatase 1
VGNC:4729
465260
Macaque
fructose-bisphosphatase 1
709022
Mouse
MGI:95492
14121
Rat
RGD:2595
24362
Dog
fructose-bisphosphatase 1
VGNC:40757
476299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fructose-bisphosphatase 1
Macaque
fructose-bisphosphatase 1
Mouse
Rat
Dog
fructose-bisphosphatase 1
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09467-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (132)
1 – 10 of 132
FBP2
Tbio
Family: Enzyme
Novelty: 0.00854851
p_int: 1
Score: 0.906
Data Source: BioPlex,STRINGDB
ST6GALNAC5
Tbio
Family: Enzyme
Novelty: 0.04754082
p_int: 0.999998849
p_ni: 0.000001145
p_wrong: 6e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
CCDC68
Tbio
Novelty: 0.1262502
p_int: 0.996340889
p_ni: 0.003647294
p_wrong: 0.000011817
Score: 0.226
Data Source: BioPlex,STRINGDB
SLAMF8
Tbio
Novelty: 0.1485993
p_int: 0.982810996
p_ni: 0.017188961
p_wrong: 4.2e-8
Score: 0.557
Data Source: BioPlex,STRINGDB
TIGD7
Tdark
Novelty: 0.38962555
p_int: 0.977344327
p_ni: 0.022588385
p_wrong: 0.000067288
Score: 0.359
Data Source: BioPlex,STRINGDB
CROT
Tbio
Family: Enzyme
Novelty: 0.01860427
p_int: 0.969960459
p_ni: 0.030036216
p_wrong: 0.000003325
Score: 0.228
Data Source: BioPlex,STRINGDB
SAMD7
Tdark
Novelty: 0.24768324
p_int: 0.954356049
p_ni: 0.045643951
Score: 0.19
Data Source: BioPlex,STRINGDB
GIMAP2
Tbio
Family: Enzyme
Novelty: 0.05969307
p_int: 0.877370699
p_ni: 0.122629299
p_wrong: 2e-9
Score: 0.203
Data Source: BioPlex,STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00208619
Score: 0.973
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  336.95

PubMed score by year
PubTator Score  132.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer