Tchem FBP1 Fructose-1,6-bisphosphatase 1

Protein Summary

Description

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09467
• O75571
• Q53F94
• Q96E46
• FBPase 1

Gene Name

• FBP1

Ensembl ID

• ENST00000375326
• ENSP00000364475
• ENSG00000165140
• ENST00000415431
• ENSP00000408025

Symbol

• FBP
• FBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
molecular function	0.96
gene perturbation	0.85
transcription factor perturbation	0.8
biological process	0.73

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Carbohydrate Phosphatase / Fructose-1,6-bisphosphatase 1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Carbohydrate Phosphatase / Fructose-1,6-bisphosphatase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.2   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 252   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 366.2   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 346

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2