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Tbio
RBP1
Retinol-binding protein 1

Protein Summary
Description
Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000492918
  • ENSP00000429166
  • ENSG00000114115
  • ENST00000617459
  • ENSP00000477621
  • ENST00000619087
  • ENSP00000482165

Symbol
  • CRBP1
  • CRBP
  • RBPC
  • CRBP1
  • CRBPI
  • CRABP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
gene perturbation
0.96
PubMedID
0.94
small molecule perturbation
0.72
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.49   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 526.49   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (82)
1 – 10 of 82
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.998345371
p_ni: 0.00088677
p_wrong: 0.000767859
Data Source: BioPlex
SOX2
Tbio
Family: TF
Novelty: 0.00037089
p_int: 0.997151973
p_ni: 0.002840178
p_wrong: 0.000007849
Score: 0.444
Data Source: BioPlex,STRINGDB
LY6D
Tbio
Novelty: 0.07032941
p_int: 0.799311732
p_ni: 0.005128673
p_wrong: 0.195559596
Data Source: BioPlex
LRAT
Tbio
Family: Enzyme
Novelty: 0.00593203
Score: 0.989
Data Source: STRINGDB
RDH11
Tbio
Family: Enzyme
Novelty: 0.02758936
Score: 0.974
Data Source: STRINGDB
STRA6
Tbio
Novelty: 0.01247638
Score: 0.974
Data Source: STRINGDB
RDH10
Tbio
Family: Enzyme
Novelty: 0.03049914
Score: 0.968
Data Source: STRINGDB
RBP4
Tchem
Novelty: 0.00168442
Score: 0.963
Data Source: STRINGDB
TTR
Tclin
Novelty: 0.0001199
Score: 0.955
Data Source: STRINGDB
DHRS9
Tbio
Family: Enzyme
Novelty: 0.00256743
Score: 0.953
Data Source: STRINGDB
Publication Statistics
PubMed Score  526.49

PubMed score by year
PubTator Score  193.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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