Tbio RBP1 Retinol-binding protein 1

Protein Summary

Description

Cytoplasmic retinol-binding protein (PubMed:22665496, PubMed:26900151, PubMed:28057518). Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis (PubMed:15632377, PubMed:22665496). This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Accession IDs

• P09455
• A8K2Q0
• B7Z7A0
• E7EWV0
• F2Z2F2
• Q6FGX8

Gene Name

• RBP1

Ensembl ID

• ENST00000492918
• ENSP00000429166
• ENSG00000114115
• ENST00000617459
• ENSP00000477621
• ENST00000619087
• ENSP00000482165

Symbol

• CRBP1
• CRBP
• RBPC
• CRBP1
• CRBPI
• CRABP-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
gene perturbation	0.96
PubMedID	0.94
small molecule perturbation	0.72
disease perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 527.21   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 435   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 527.21   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0