You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TNP1
Spermatid nuclear transition protein 1

Protein Summary
Description
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236979
  • ENSP00000236979
  • ENSG00000118245

Symbol
  • TP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
cellular component
0.63
co-expressed gene
0.61
cell line
0.51
virus perturbation
0.5


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transition protein 1
VGNC:2891
740418
Mouse
MGI:98784
21958
Rat
RGD:3884
24839
Dog
transition protein 1
VGNC:47693
100686780
Horse
transition protein 1
VGNC:24393
100630835
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transition protein 1
Mouse
Rat
Dog
transition protein 1
Horse
transition protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P09430-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (93)
1 – 10 of 93
TNP2
Tbio
Novelty: 0.01170636
Score: 0.972
Data Source: STRINGDB
PRM2
Tbio
Novelty: 0.0050028
Score: 0.899
Data Source: STRINGDB
PRM1
Tbio
Novelty: 0.009665
Score: 0.82
Data Source: STRINGDB
HIST3H3
Tbio
Novelty: 0.04915012
Score: 0.782
Data Source: STRINGDB
HIST1H4A
Tbio
Novelty: 0.00279614
Score: 0.776
Data Source: STRINGDB
PRM3
Tdark
Novelty: 0.03634194
Score: 0.756
Data Source: STRINGDB
NUPR1
Tbio
Novelty: 0.00934603
Score: 0.75
Data Source: STRINGDB
HIST3H2A
Tbio
Novelty: 0.34036249
Score: 0.748
Data Source: STRINGDB
KDM3A
Tchem
Family: Epigenetic
Novelty: 0.0101705
Score: 0.744
Data Source: STRINGDB
CENPA
Tbio
Novelty: 0.00154245
Score: 0.729
Data Source: STRINGDB
Publication Statistics
PubMed Score  80.91

PubMed score by year
PubTator Score  182.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer