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Tchem
HMGB1
High mobility group protein B1

Protein Summary
Description
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339872
  • ENSP00000343040
  • ENSG00000189403
  • ENST00000341423
  • ENSP00000345347
  • ENST00000399494
  • ENSP00000382417
  • ENST00000405805
  • ENSP00000384678

Symbol
  • HMG1
  • HMG1
  • HMG3
  • HMG-1
  • SBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
hub protein
0.99
biological process
0.98
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3219.46   (req: < 5)
Gene RIFs: 847   (req: <= 3)
Antibodies: 1545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3219.46   (req: >= 5)
Gene RIFs: 847   (req: > 3)
Antibodies: 1545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 108
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2