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Tbio
HMGB1
High mobility group protein B1

Protein Summary
Description
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury (PubMed:27362237). Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA) ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339872
  • ENSP00000343040
  • ENSG00000189403
  • ENST00000341423
  • ENSP00000345347
  • ENST00000399494
  • ENSP00000382417
  • ENST00000405805
  • ENSP00000384678

Symbol
  • HMG1
  • HMG1
  • HMG3
  • HMG-1
  • SBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
transcription factor perturbation
1
hub protein
0.99
biological process
0.98
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2869.82   (req: < 5)
Gene RIFs: 847   (req: <= 3)
Antibodies: 1545   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2869.82   (req: >= 5)
Gene RIFs: 847   (req: > 3)
Antibodies: 1545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 108
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
1
2
88
body mass index
1
1
1
79.5
eosinophil count
2
2
3
79.3
mean corpuscular hemoglobin concentration
1
1
1
74.3
BMI-adjusted waist-hip ratio
1
1
1
65.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
2
88
body mass index
1
79.5
eosinophil count
3
79.3
mean corpuscular hemoglobin concentration
1
74.3
BMI-adjusted waist-hip ratio
1
65.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96113
15289
Rat
RGD:11468204
108349189
Dog
high mobility group box 1
403170
Horse
high mobility group box 1
100033873
Cow
high mobility group box 1
VGNC:53816
282691
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
high mobility group box 1
Horse
high mobility group box 1
Cow
high mobility group box 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09429-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1121)
Advanced glycosylation endproduct receptor signaling (R-HSA-879415)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Advanced glycosylation endproduct receptor signaling
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cytokine Signaling in Immune system
Gene Ontology Terms (123)
Items per page:
10
1 – 10 of 25
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (243)
1 – 10 of 243
SP100
Tbio
Family: TF; Epigenetic
Novelty: 0.00201806
p_int: 0.999999995
p_wrong: 5e-9
Score: 0.419
Data Source: BioPlex,STRINGDB
HMGB1P1
Tdark
p_int: 0.999999989
p_ni: 1.1e-8
Data Source: BioPlex
POTEE
Tbio
Novelty: 0.29349205
p_int: 0.999991988
p_ni: 0.000007248
p_wrong: 7.63e-7
Score: 0.234
Data Source: BioPlex,STRINGDB
ATP2A1
Tchem
Family: Transporter
Novelty: 0.00355092
p_int: 0.957062597
p_ni: 0.042937403
Score: 0.249
Data Source: BioPlex,STRINGDB
GFAP
Tbio
Novelty: 0.00020932
p_int: 0.943337973
p_ni: 0.055278411
p_wrong: 0.001383616
Score: 0.359
Data Source: BioPlex,STRINGDB
TUBA3C
Tchem
Novelty: 0.0187396
p_int: 0.928712611
p_ni: 0.071287389
Score: 0.19
Data Source: BioPlex,STRINGDB
HMGB2
Tbio
Family: TF
Novelty: 0.01761676
Score: 0.998
Data Source: STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.996
Data Source: Reactome,STRINGDB
AGER
Tchem
Novelty: 0.00061101
Score: 0.996
Data Source: STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  2869.82

PubMed score by year
PubTator Score  1871.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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