Protein Classes
Protein Summary
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
- ENST00000215909
- ENSP00000215909
- ENSG00000100097
- GBP
- GAL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
interacting protein | 0.98 | ||
transcription factor perturbation | 0.98 | ||
PubMedID | 0.96 | ||
disease perturbation | 0.93 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 968.27 (req: < 5)
Gene RIFs: 310 (req: <= 3)
Antibodies: 842 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 968.27 (req: >= 5)
Gene RIFs: 310 (req: > 3)
Antibodies: 842 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
Protein Data Bank (30)
1 – 5 of 30
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (6)
Reactome (4)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Gene Ontology Terms (31)
Functions (4)
Components (10)
Processes (17)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (226)
1 – 10 of 226
LRFN4
Novelty: 0.12511571
p_int: 0.999806548
p_ni: 0.000193452
Data Source: BioPlex
ALCAM
Novelty: 0.00244371
p_int: 0.999666664
p_ni: 0.000333316
p_wrong: 2e-8
Score: 0.369
Data Source: BioPlex,STRINGDB
SEMA4C
Novelty: 0.01237067
p_int: 0.999386782
p_ni: 0.000613218
Data Source: BioPlex
LINGO2
Novelty: 0.06112205
p_int: 0.992450928
p_ni: 0.007549009
p_wrong: 6.3e-8
Data Source: BioPlex
CD68
Novelty: 0.00017859
p_int: 0.988327051
p_ni: 0.011672602
p_wrong: 3.47e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
PECAM1
Novelty: 0.00013373
p_int: 0.987617048
p_ni: 0.012382788
p_wrong: 1.64e-7
Score: 0.379
Data Source: BioPlex,STRINGDB
FAM24B
Novelty: 1.04675689
p_int: 0.977558999
p_ni: 0.022389325
p_wrong: 0.000051676
Data Source: BioPlex
CDHR5
Novelty: 0.08525208
p_int: 0.976479912
p_ni: 0.023519826
p_wrong: 2.62e-7
Data Source: BioPlex
S1PR2
Family: GPCR
Novelty: 0.00372765
p_int: 0.976311571
p_ni: 0.023688309
p_wrong: 1.2e-7
Data Source: BioPlex
NTRK3
Family: Kinase
Novelty: 0.00177321
p_int: 0.976227229
p_ni: 0.023772515
p_wrong: 2.56e-7
Data Source: BioPlex
Publication Statistics
PubMed Score 968.27
PubMed score by year
PubTator Score 1672.98
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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