Protein Summary
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
- ENST00000215909
- ENSP00000215909
- ENSG00000100097
- GBP
- GAL1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
interacting protein | 0.98 | ||
transcription factor perturbation | 0.98 | ||
PubMedID | 0.96 | ||
disease perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 985.22 (req: < 5)
Gene RIFs: 310 (req: <= 3)
Antibodies: 842 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 985.22 (req: >= 5)
Gene RIFs: 310 (req: > 3)
Antibodies: 842 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (10)
Protein-Protein Interactions (226)
ALCAM
Novelty: 0.00244371
p_int: 0.999666664
p_ni: 0.000333316
p_wrong: 2e-8
Score: 0.369
Data Source: BioPlex,STRINGDB
LINGO2
Novelty: 0.06112205
p_int: 0.992450928
p_ni: 0.007549009
p_wrong: 6.3e-8
Data Source: BioPlex
CD68
Novelty: 0.00017859
p_int: 0.988327051
p_ni: 0.011672602
p_wrong: 3.47e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
PECAM1
Novelty: 0.00013373
p_int: 0.987617048
p_ni: 0.012382788
p_wrong: 1.64e-7
Score: 0.379
Data Source: BioPlex,STRINGDB
FAM24B
Novelty: 1.04675689
p_int: 0.977558999
p_ni: 0.022389325
p_wrong: 0.000051676
Data Source: BioPlex
CDHR5
Novelty: 0.08525208
p_int: 0.976479912
p_ni: 0.023519826
p_wrong: 2.62e-7
Data Source: BioPlex
S1PR2
Family: GPCR
Novelty: 0.00372765
p_int: 0.976311571
p_ni: 0.023688309
p_wrong: 1.2e-7
Data Source: BioPlex
NTRK3
Family: Kinase
Novelty: 0.00177321
p_int: 0.976227229
p_ni: 0.023772515
p_wrong: 2.56e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (6)
Reactome (4)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (4)
Components (10)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
basophil count | 2 | 2 | 2 | 58.9 | |||||
age-related hearing impairment | 2 | 1 | 1 | 1.1 | 52.7 | ||||
serum albumin measurement | 1 | 1 | 1 | 50.6 | |||||
pulse pressure measurement | 1 | 1 | 1 | 46.9 | |||||
cognitive function measurement | 3 | 1 | 3 | 44.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
basophil count | 2 | 58.9 | |||||
age-related hearing impairment | 1 | 1.1 | 52.7 | ||||
serum albumin measurement | 1 | 50.6 | |||||
pulse pressure measurement | 1 | 46.9 | |||||
cognitive function measurement | 3 | 44.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | galectin 1 | VGNC:10089 | 742148 | |||||
Macaque | galectin 1 | 700896 | ||||||
Mouse | MGI:96777 | 16852 | ||||||
Rat | RGD:69355 | 56646 | ||||||
Dog | galectin 1 | 610276 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | galectin 1 | |||||
Macaque | galectin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | galectin 1 | |||||
Publication Statistics
PubMed Score 985.22
PubMed score by year
PubTator Score 1672.98
PubTator score by year
Related Publications
Text Mined References (371)
GeneRif Annotations (310)
Items per page:
0 of 0
PMID | Year | Title |
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