You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CXCL1
Growth-regulated alpha protein

Protein Summary
Description
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395761
  • ENSP00000379110
  • ENSG00000163739

Symbol
  • GRO
  • GRO1
  • GROA
  • MGSA
  • SCYB1
  • FSP
  • GRO1
  • GROa
  • MGSA
  • NAP-3
  • SCYB1
  • MGSA-a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
biological term
0.88
gene perturbation
0.83
transcription factor perturbation
0.8
disease
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2032.83   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2032.83   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (514)
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.999995556
p_ni:  0.000004444
Score:  0.214
Data Source:  BioPlex,STRINGDB
CXCL2
Tbio
Novelty:  0.00201175
p_int:  0.999880922
p_ni:  1e-9
p_wrong:  0.000119077
Score:  0.98
Data Source:  BioPlex,STRINGDB
CXCL3
Tbio
Novelty:  0.01001656
p_int:  0.999862915
p_ni:  1e-9
p_wrong:  0.000137085
Score:  0.966
Data Source:  BioPlex,STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.999680338
p_ni:  0.000319662
Data Source:  BioPlex
SEH1L
Tbio
Novelty:  0.03666501
p_int:  0.906294363
p_ni:  0.093705637
Data Source:  BioPlex
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.825003364
p_ni:  0.173817843
p_wrong:  0.001178793
Score:  0.174
Data Source:  BioPlex,STRINGDB
CXCR2
Tchem
Family:  GPCR
Novelty:  0.00108314
Score:  0.995
Data Source:  STRINGDB
CCL20
Tbio
Novelty:  0.00158263
Score:  0.988
Data Source:  STRINGDB
CXCL6
Tbio
Novelty:  0.01019922
Score:  0.988
Data Source:  STRINGDB
CXCL10
Tbio
Novelty:  0.00040194
Score:  0.987
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (32)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
46
11
50
98.7
C-X-C motif chemokine 6 measurement
2
2
3
95.9
growth-regulated alpha protein measurement
2
4
2
1.1
94.7
CXCL6 measurement
2
2
2
92.8
neutrophil count
3
5
6
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
50
98.7
C-X-C motif chemokine 6 measurement
3
95.9
growth-regulated alpha protein measurement
2
1.1
94.7
CXCL6 measurement
2
92.8
neutrophil count
6
90.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 1
VGNC:8658
740567
Macaque
chemokine (C-X-C motif) ligand 3
574223
Horse
CXCL3
100056258
Horse
chemokine (C-X-C motif) ligand 2
100233237
Opossum
growth-regulated alpha protein
100023783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 1
Macaque
chemokine (C-X-C motif) ligand 3
Horse
CXCL3
Horse
chemokine (C-X-C motif) ligand 2
Opossum
growth-regulated alpha protein
Publication Statistics
PubMed Score 2032.83
PubMed score by year
PubTator Score 524.22
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title