You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CXCL1
Growth-regulated alpha protein

Protein Summary
Description
Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395761
  • ENSP00000379110
  • ENSG00000163739

Symbol
  • GRO
  • GRO1
  • GROA
  • MGSA
  • SCYB1
  • FSP
  • GRO1
  • GROa
  • MGSA
  • NAP-3
  • SCYB1
  • MGSA-a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.99
biological term
0.88
gene perturbation
0.83
transcription factor perturbation
0.8
disease
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1548.93   (req: < 5)
Gene RIFs: 167   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1548.93   (req: >= 5)
Gene RIFs: 167   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth-regulated alpha protein measurement
1
1
1
24.3
neutrophil count
1
1
1
3.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth-regulated alpha protein measurement
1
24.3
neutrophil count
1
3.3
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (32)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytokine Signaling in Immune system
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Cytokine Signaling in Immune system
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (514)
1 – 10 of 514
BIRC2
Tchem
Novelty: 0.00199701
p_int: 0.999995556
p_ni: 0.000004444
Score: 0.214
Data Source: BioPlex,STRINGDB
CXCL2
Tbio
Novelty: 0.00201175
p_int: 0.999880922
p_ni: 1e-9
p_wrong: 0.000119077
Score: 0.98
Data Source: BioPlex,STRINGDB
CXCL3
Tbio
Novelty: 0.01001656
p_int: 0.999862915
p_ni: 1e-9
p_wrong: 0.000137085
Score: 0.966
Data Source: BioPlex,STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
p_int: 0.999680338
p_ni: 0.000319662
Data Source: BioPlex
SEH1L
Tbio
Novelty: 0.03666501
p_int: 0.906294363
p_ni: 0.093705637
Data Source: BioPlex
XIAP
Tchem
Family: Enzyme
Novelty: 0.00062268
p_int: 0.825003364
p_ni: 0.173817843
p_wrong: 0.001178793
Score: 0.174
Data Source: BioPlex,STRINGDB
CXCR2
Tchem
Family: GPCR
Novelty: 0.00108314
Score: 0.995
Data Source: STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.988
Data Source: STRINGDB
CXCL6
Tbio
Novelty: 0.01019922
Score: 0.988
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.987
Data Source: STRINGDB
Publication Statistics
PubMed Score  1548.93

PubMed score by year
PubTator Score  524.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer