Tbio CXCL1 Growth-regulated alpha protein

Protein Summary

Description

Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P09341
• Q9UCR7

Gene Name

• CXCL1

Ensembl ID

• ENST00000395761
• ENSP00000379110
• ENSG00000163739

Symbol

• GRO
• GRO1
• GROA
• MGSA
• SCYB1
• FSP
• GRO1
• GROa
• MGSA
• NAP-3
• SCYB1
• MGSA-a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.99
biological term	0.88
gene perturbation	0.83
transcription factor perturbation	0.8
disease	0.78

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Chemokine / Growth-regulated Alpha Protein

DTO Classes

Protein / Signaling / Chemokine / Growth-regulated Alpha Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2032.83   (req: < 5)

Gene RIFs: 227   (req: <= 3)

Antibodies: 720   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2032.83   (req: >= 5)

Gene RIFs: 227   (req: > 3)

Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0