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Tbio
CD48
CD48 antigen

Protein Summary
Description
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368045
  • ENSP00000357024
  • ENSG00000117091
  • ENST00000368046
  • ENSP00000357025

Symbol
  • BCM1
  • BLAST1
  • BCM1
  • BLAST
  • hCD48
  • mCD48
  • BLAST1
  • SLAMF2
  • MEM-102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
protein domain
0.73
kinase perturbation
0.71
cellular component
0.67
tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.41   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 956   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 372.41   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 956   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
11.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD48 molecule
VGNC:5013
457437
Macaque
CD48 molecule
719762
Mouse
MGI:88339
12506
Rat
RGD:620620
245962
Dog
CD48 molecule
VGNC:38961
488642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD48 molecule
Macaque
CD48 molecule
Mouse
Rat
Dog
CD48 molecule
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (165)
1 – 10 of 165
PRAP1
Tbio
Novelty: 0.08146257
p_int: 0.999995901
p_ni: 0.000003918
p_wrong: 1.81e-7
Score: 0.68
Data Source: BioPlex,STRINGDB
CD244
Tbio
Novelty: 0.01137579
Score: 0.997
Data Source: Reactome,STRINGDB
CD2
Tclin
Novelty: 0.00037283
Score: 0.942
Data Source: STRINGDB
CD53
Tbio
Novelty: 0.01722633
Score: 0.867
Data Source: STRINGDB
PTPRC
Tchem
Family: Enzyme
Novelty: 0.00012027
Score: 0.854
Data Source: STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.816
Data Source: STRINGDB
CD84
Tbio
Novelty: 0.02811289
Score: 0.771
Data Source: STRINGDB
LY9
Tbio
Novelty: 0.01892831
Score: 0.767
Data Source: STRINGDB
CD52
Tclin
Novelty: 0.00142013
Score: 0.761
Data Source: STRINGDB
SLAMF6
Tbio
Novelty: 0.01459284
Score: 0.758
Data Source: STRINGDB
Publication Statistics
PubMed Score  372.41

PubMed score by year
PubTator Score  230.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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