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Tchem
MMP10
Stromelysin-2

Protein Summary
Description
Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down fibronectin, laminin, elastin, proteoglycan core protein, gelatins, and several types of collagen. The gene is part of a cluster of MMP genes on chromosome 11. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279441
  • ENSP00000279441
  • ENSG00000166670

Symbol
  • STMY2
  • SL-2
  • STMY2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
1
cell type or tissue
0.78
disease
0.74
biological term
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 876.69   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 585   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 876.69   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 585   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 1 measurement
1
1
1
78.2
matrix metalloproteinase 10 measurement
1
1
1
45.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
matrix metalloproteinase 1 measurement
1
78.2
matrix metalloproteinase 10 measurement
1
45.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 10
VGNC:1098
740658
Macaque
matrix metallopeptidase 10
701793
Mouse
MGI:97007
17384
Rat
RGD:620192
117061
Chicken
matrix metallopeptidase 10
CGNC:50887
418981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrix metallopeptidase 10
Macaque
matrix metallopeptidase 10
Mouse
Rat
Chicken
matrix metallopeptidase 10
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09238-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (25)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Collagen degradation
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Reactome
MAPK family signaling cascades
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Collagen degradation
Degradation of the extracellular matrix
Extracellular matrix organization
MAPK family signaling cascades
Protein-Protein Interactions (80)
1 – 10 of 80
MMP3
Tchem
Novelty: 0.00041675
p_int: 1
Score: 0.987
Data Source: BioPlex,STRINGDB
GAL
Tbio
Novelty: 0.0005132
p_int: 0.999916822
p_ni: 0.000079412
p_wrong: 0.000003766
Score: 0.187
Data Source: BioPlex,STRINGDB
PCSK1N
Tbio
Novelty: 0.02656799
p_int: 0.999437724
p_ni: 0.000011532
p_wrong: 0.000550745
Score: 0.187
Data Source: BioPlex,STRINGDB
APOE
Tbio
Novelty: 0.00005049
p_int: 0.997865595
p_ni: 0.002132562
p_wrong: 0.000001842
Score: 0.694
Data Source: BioPlex,STRINGDB
TIMP1
Tbio
Family: Enzyme
Novelty: 0.00020986
p_int: 0.995707391
p_ni: 0.004180686
p_wrong: 0.000111922
Score: 0.957
Data Source: BioPlex,STRINGDB
LTBP1
Tbio
Novelty: 0.00958396
p_int: 0.994657968
p_ni: 0.005342031
p_wrong: 1e-9
Score: 0.253
Data Source: BioPlex,STRINGDB
TRAF7
Tbio
Family: Enzyme
Novelty: 0.02437761
p_int: 0.966210739
p_ni: 0.033597616
p_wrong: 0.000191646
Data Source: BioPlex
B4GALT1
Tbio
Family: Enzyme
Novelty: 0.0073693
p_int: 0.938743138
p_ni: 0.061256689
p_wrong: 1.73e-7
Score: 0.177
Data Source: BioPlex,STRINGDB
MAN1A1
Tbio
Family: Enzyme
Novelty: 0.00645679
p_int: 0.877093497
p_ni: 0.122906502
Score: 0.167
Data Source: BioPlex,STRINGDB
EMILIN3
Tbio
Novelty: 0.4
p_int: 0.852677616
p_ni: 0.147322384
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  876.69

PubMed score by year
PubTator Score  281.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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