Protein Summary
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan ...more
- ENST00000260227
- ENSP00000260227
- ENSG00000137673
- MPSL1
- PUMP1
- MMP-7
- MPSL1
- PUMP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
protein domain | 0.92 | ||
gene perturbation | 0.88 | ||
disease | 0.69 | ||
chemical | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1317.56 (req: < 5)
Gene RIFs: 426 (req: <= 3)
Antibodies: 770 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1317.56 (req: >= 5)
Gene RIFs: 426 (req: > 3)
Antibodies: 770 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 224
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0