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Tchem
GSTP1
Glutathione S-transferase P

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398606
  • ENSP00000381607
  • ENSG00000084207
  • ENST00000642444
  • ENSP00000493538

Symbol
  • FAEES3
  • GST3
  • PI
  • DFN7
  • GST3
  • GSTP
  • FAEES3
  • HEL-S-22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
transcription factor perturbation
0.99
biological process
0.97
disease perturbation
0.97
cell type or tissue
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2369.03   (req: < 5)
Gene RIFs: 863   (req: <= 3)
Antibodies: 735   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2369.03   (req: >= 5)
Gene RIFs: 863   (req: > 3)
Antibodies: 735   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 36
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
Vitamin E
no chemical structure image available
Active Ligands (36)
1 – 10 of 36
CHEMBL379437
Rendered image for CHEMBL379437
CHEMBL209755
Rendered image for CHEMBL209755
CHEMBL3360523
Rendered image for CHEMBL3360523
CHEMBL3360520
Rendered image for CHEMBL3360520
CHEMBL216505
Rendered image for CHEMBL216505
CHEMBL3360522
Rendered image for CHEMBL3360522
CHEMBL3360504
Rendered image for CHEMBL3360504
CHEMBL3360532
Rendered image for CHEMBL3360532
CHEMBL3360531,CHEMBL2430532
Rendered image for CHEMBL3360531,CHEMBL2430532
CHEMBL3360530
Rendered image for CHEMBL3360530
Protein-Protein Interactions (195)
1 – 10 of 195
PRDX6
Tbio
Novelty:  0.00180564
Score:  0.967
Data Source:  Reactome,STRINGDB
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.94
Data Source:  STRINGDB
GSTT2B
Tbio
Family:  Enzyme
Novelty:  0.02334158
Score:  0.923
Data Source:  STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.914
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.908
Data Source:  STRINGDB
GSTO1
Tchem
Family:  Enzyme
Novelty:  0.00800915
Score:  0.897
Data Source:  STRINGDB
GSTO2
Tbio
Family:  Enzyme
Novelty:  0.01836256
Score:  0.889
Data Source:  STRINGDB
CYP2E1
Tchem
Novelty:  0.00030504
Score:  0.886
Data Source:  STRINGDB
CYP1B1
Tchem
Novelty:  0.00090917
Score:  0.885
Data Source:  STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.878
Data Source:  STRINGDB
Pathways (29)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
Glutathione conjugation
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Glutathione conjugation
Gene Ontology Terms (64)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
3
4
90
BMI-adjusted hip circumference
2
3
3
81.5
urinary metabolite measurement
1
1
1
51.4
BMI-adjusted waist-hip ratio
1
1
1
21.5
serum metabolite measurement
1
1
1
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
4
90
BMI-adjusted hip circumference
3
81.5
urinary metabolite measurement
1
51.4
BMI-adjusted waist-hip ratio
1
21.5
serum metabolite measurement
1
21.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase pi 1
VGNC:6750
745954
Macaque
glutathione S-transferase pi 1
721704
Mouse
MGI:95864
14869
Mouse
MGI:95865
14870
Rat
RGD:2758
24426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutathione S-transferase pi 1
Macaque
glutathione S-transferase pi 1
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 2369.03
PubMed score by year
PubTator Score 1454.09
PubTator score by year