Protein Summary
Conversion of dopamine to noradrenaline. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
- ENST00000393056
- ENSP00000376776
- ENSG00000123454
- DBM
- ORTHYP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
biological process | 0.86 | ||
disease | 0.84 | ||
biological term | 0.83 | ||
molecular function | 0.73 | ||
IDG Partner Tools
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1070.21 (req: < 5)
Gene RIFs: 132 (req: <= 3)
Antibodies: 496 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1070.21 (req: >= 5)
Gene RIFs: 132 (req: > 3)
Antibodies: 496 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (3)
1 – 3 of 3
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 2 | 1 | 2 | 95.5 | |||||
smoking cessation | 2 | 2 | 2 | 94.3 | |||||
diastolic blood pressure | 1 | 1 | 1 | 73 | |||||
Calcium channel blocker use measurement | 1 | 1 | 1 | 20.9 | |||||
electrocardiography | 1 | 1 | 1 | 7.4 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cigarettes per day measurement | 2 | 95.5 | |||||
smoking cessation | 2 | 94.3 | |||||
diastolic blood pressure | 1 | 73 | |||||
Calcium channel blocker use measurement | 1 | 20.9 | |||||
electrocardiography | 1 | 7.4 | |||||
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (15)
Reactome (4)
KEGG (2)
PathwayCommons (4)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Catecholamine biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Catecholamine biosynthesis | ||||
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Gene Ontology Terms (41)
Functions (5)
Components (13)
Processes (23)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (116)
1 – 10 of 116
LEMD3
Novelty: 0.00579701
p_int: 0.991858612
p_ni: 0.008141388
Data Source: BioPlex
RPL23
Novelty: 0.02741113
p_int: 0.792156971
p_ni: 0.207843029
Data Source: BioPlex
PNMT
Family: Enzyme
Novelty: 0.00178141
Score: 0.99
Data Source: STRINGDB
DDC
Family: Enzyme
Novelty: 0.0012284
Score: 0.989
Data Source: STRINGDB
COMT
Family: Enzyme
Novelty: 0.00025107
Score: 0.968
Data Source: STRINGDB
TH
Family: Enzyme
Novelty: 0.00025719
Score: 0.962
Data Source: STRINGDB
MAOA
Family: Enzyme
Novelty: 0.00031037
Score: 0.957
Data Source: STRINGDB
MAOB
Family: Enzyme
Novelty: 0.00030366
Score: 0.951
Data Source: STRINGDB
AOC3
Family: Enzyme
Novelty: 0.00078739
Score: 0.912
Data Source: STRINGDB
AOC2
Family: Enzyme
Novelty: 0.0048282
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score 1070.21
PubMed score by year
PubTator Score 1625.46
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword
GWAS Trait