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Tchem
DBH
Dopamine beta-hydroxylase

Protein Summary
Description
Conversion of dopamine to noradrenaline. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393056
  • ENSP00000376776
  • ENSG00000123454

Symbol
  • DBM
  • ORTHYP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.86
disease
0.84
biological term
0.83
molecular function
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1075.78   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1075.78   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (116)
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.991858612
p_ni:  0.008141388
Data Source:  BioPlex
RPL23
Tbio
Novelty:  0.02741113
p_int:  0.792156971
p_ni:  0.207843029
Data Source:  BioPlex
PNMT
Tchem
Family:  Enzyme
Novelty:  0.00178141
Score:  0.99
Data Source:  STRINGDB
DDC
Tclin
Family:  Enzyme
Novelty:  0.0012284
Score:  0.989
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.968
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.962
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.957
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.951
Data Source:  STRINGDB
AOC3
Tchem
Family:  Enzyme
Novelty:  0.00078739
Score:  0.912
Data Source:  STRINGDB
AOC2
Tchem
Family:  Enzyme
Novelty:  0.0048282
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 3 of 3
MAOA
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
COMT
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
MAOB
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (15)
Catecholamine biosynthesis (R-HSA-209905)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Catecholamine biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Catecholamine biosynthesis
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (41)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
3
6
8
97.5
cigarettes per day measurement
3
5
6
96.7
smoking behaviour measurement
1
1
1
81.9
diastolic blood pressure
1
1
1
70.2
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking cessation
8
97.5
cigarettes per day measurement
6
96.7
smoking behaviour measurement
1
81.9
diastolic blood pressure
1
70.2
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dopamine beta-hydroxylase
VGNC:8813
464827
Macaque
dopamine beta-hydroxylase
574105
Mouse
MGI:94864
13166
Rat
RGD:2489
25699
Dog
dopamine beta-hydroxylase
VGNC:39781
448806
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dopamine beta-hydroxylase
Macaque
dopamine beta-hydroxylase
Mouse
Rat
Dog
dopamine beta-hydroxylase
Publication Statistics
PubMed Score 1075.78
PubMed score by year
PubTator Score 1625.46
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title