Protein Summary
Conversion of dopamine to noradrenaline. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
- ENST00000393056
- ENSP00000376776
- ENSG00000123454
- DBM
- ORTHYP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
biological process | 0.86 | ||
disease | 0.84 | ||
biological term | 0.83 | ||
molecular function | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1075.78 (req: < 5)
Gene RIFs: 132 (req: <= 3)
Antibodies: 496 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1075.78 (req: >= 5)
Gene RIFs: 132 (req: > 3)
Antibodies: 496 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (3)
Protein-Protein Interactions (116)
Nearest Tclin Targets (7)
Upstream (3)
Downstream (4)
Pathways (15)
Reactome (4)
KEGG (2)
PathwayCommons (4)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Catecholamine biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of amine-derived hormones | ||||
Reactome | Metabolism of amino acids and derivatives | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Catecholamine biosynthesis | ||||
Metabolism | ||||
Metabolism of amine-derived hormones | ||||
Metabolism of amino acids and derivatives | ||||
Viral Interactions (0)
Gene Ontology Terms (41)
Functions (5)
Components (13)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking cessation | 3 | 6 | 8 | 97.5 | |||||
cigarettes per day measurement | 3 | 5 | 6 | 96.7 | |||||
smoking behaviour measurement | 1 | 1 | 1 | 81.9 | |||||
diastolic blood pressure | 1 | 1 | 1 | 70.2 | |||||
1 | 1 | 1 | 58.4 | ||||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking cessation | 8 | 97.5 | |||||
cigarettes per day measurement | 6 | 96.7 | |||||
smoking behaviour measurement | 1 | 81.9 | |||||
diastolic blood pressure | 1 | 70.2 | |||||
1 | 58.4 | ||||||
Find similar targets by:
IDG Resources
Orthologs (15)
1 – 5 of 15
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dopamine beta-hydroxylase | VGNC:8813 | 464827 | |||||
Macaque | dopamine beta-hydroxylase | 574105 | ||||||
Mouse | MGI:94864 | 13166 | ||||||
Rat | RGD:2489 | 25699 | ||||||
Dog | dopamine beta-hydroxylase | VGNC:39781 | 448806 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dopamine beta-hydroxylase | |||||
Macaque | dopamine beta-hydroxylase | |||||
Mouse | ||||||
Rat | ||||||
Dog | dopamine beta-hydroxylase | |||||
Publication Statistics
PubMed Score 1075.78
PubMed score by year
PubTator Score 1625.46
PubTator score by year
Related Publications
Text Mined References (201)
GeneRif Annotations (132)
Items per page:
0 of 0
PMID | Year | Title |
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