You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POU2F2
POU domain, class 2, transcription factor 2

Protein Summary
Description
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389341
  • ENSP00000373992
  • ENSG00000028277
  • ENST00000526816
  • ENSP00000431603
  • ENST00000529067
  • ENSP00000437224
  • ENST00000529952
  • ENSP00000436988

Symbol
  • OCT2
  • OTF2
  • OCT2
  • OTF2
  • Oct-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.72
transcription factor
0.62
histone modification site profile
0.61
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.33   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 525   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.33   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 525   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
2
2
67.5
eosinophil count
2
1
2
66.4
diet measurement
1
1
1
15
prostate carcinoma
1
1
0
1.1
2.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
67.5
eosinophil count
2
66.4
diet measurement
1
15
prostate carcinoma
0
1.1
2.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 2 homeobox 2
VGNC:12061
740346
Macaque
POU class 2 homeobox 2
706835
Mouse
MGI:101897
18987
Rat
RGD:621690
117058
Dog
POU class 2 homeobox 2
VGNC:44827
484478
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 2 homeobox 2
Macaque
POU class 2 homeobox 2
Mouse
Rat
Dog
POU class 2 homeobox 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09086-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (119)
1 – 10 of 119
TMEM108
Tbio
Novelty: 0.08687599
p_int: 0.999353214
p_ni: 0.000003707
p_wrong: 0.000643079
Score: 0.277
Data Source: BioPlex,STRINGDB
TBP
Tbio
Novelty: 0.00034941
Score: 0.946
Data Source: STRINGDB
ZNF143
Tbio
Family: TF
Novelty: 0.00622649
Score: 0.939
Data Source: Reactome,STRINGDB
GTF2F1
Tbio
Novelty: 0.02118098
Score: 0.926
Data Source: STRINGDB
GTF2B
Tbio
Novelty: 0.00179492
Score: 0.923
Data Source: STRINGDB
CCNT2
Tbio
Novelty: 0.04593314
Score: 0.919
Data Source: STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.917
Data Source: STRINGDB
ELL2
Tbio
Family: Enzyme
Novelty: 0.040736
Score: 0.915
Data Source: STRINGDB
POU2F1
Tbio
Family: TF
Novelty: 0.00722164
Score: 0.907
Data Source: STRINGDB
POLR2A
Tbio
Family: Enzyme
Novelty: 0.00188323
Score: 0.907
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.33

PubMed score by year
PubTator Score  522.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: