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Tchem
FGF2
Fibroblast growth factor 2

Protein Summary
Description
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with disti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000608478
  • ENSP00000477134
  • ENSG00000138685
  • ENST00000614010
  • ENSP00000478620
  • ENST00000644866
  • ENSP00000494222

Symbol
  • FGFB
  • BFGF
  • FGFB
  • FGF-2
  • HBGF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
0.96
pathway
0.8
disease
0.78
microRNA
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14113.32   (req: < 5)
Gene RIFs: 627   (req: <= 3)
Antibodies: 1047   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14113.32   (req: >= 5)
Gene RIFs: 627   (req: > 3)
Antibodies: 1047   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (647)
IL7R
Tbio
Novelty:  0.00107223
p_int:  0.999999774
p_ni:  2.2e-7
p_wrong:  6e-9
Data Source:  BioPlex
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999999577
p_ni:  4.23e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SDC2
Tbio
Novelty:  0.00597758
p_int:  0.999999424
p_ni:  5.61e-7
p_wrong:  1.5e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
CD44
Tbio
Novelty:  0.00011321
p_int:  0.999998694
p_ni:  6.1e-8
p_wrong:  0.000001246
Score:  0.89
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.999918517
p_ni:  0.00000195
p_wrong:  0.000079534
Score:  0.981
Data Source:  BioPlex,STRINGDB
TMEFF1
Tbio
Novelty:  0.11856207
p_int:  0.9994368
p_ni:  6.34e-7
p_wrong:  0.000562566
Score:  0.351
Data Source:  BioPlex,STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
Score:  0.998
Data Source:  STRINGDB
FGFR3
Tclin
Family:  Kinase
Novelty:  0.00071612
Score:  0.993
Data Source:  STRINGDB
FGFR4
Tclin
Family:  Kinase
Novelty:  0.00258329
Score:  0.993
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets (18)
Explore Nearest Tclin Targets
Pathways (124)
Activated point mutants of FGFR2 (R-HSA-2033519)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 83
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated point mutants of FGFR2
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Activated point mutants of FGFR2
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (65)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
MGI
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibroblast growth factor 2 measurement
1
1
1
83.4
type 2 diabetes mellitus
1
1
1
33.1
body weight
1
1
1
26.8
BMI-adjusted waist circumference
1
1
1
19.6
lymphocyte count
3
1
3
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibroblast growth factor 2 measurement
1
83.4
type 2 diabetes mellitus
1
33.1
body weight
1
26.8
BMI-adjusted waist circumference
1
19.6
lymphocyte count
3
18.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 2
641462
Macaque
fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676]
Mouse
MGI:95516
14173
Rat
RGD:2609
54250
Dog
fibroblast growth factor 2
VGNC:40847
403857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibroblast growth factor 2
Macaque
fibroblast growth factor 2 [Source:HGNC Symbol;Acc:HGNC:3676]
Mouse
Rat
Dog
fibroblast growth factor 2
Publication Statistics
PubMed Score 14113.32
PubMed score by year
PubTator Score 4657.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title