Tchem FGF2 Fibroblast growth factor 2

Protein Summary

Description

Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09038
• A4LBB8
• O00527
• P78443
• Q16443
• Q5PY50
• Q7KZ11
• Q7KZ72
• Q9UC54
• Q9UCS5
• Q9UCS6
• FGF-2

Gene Name

• FGF2

Ensembl ID

• ENST00000608478
• ENSP00000477134
• ENSG00000138685
• ENST00000614010
• ENSP00000478620
• ENST00000644866
• ENSP00000494222

Symbol

• FGFB
• BFGF
• FGFB
• FGF-2
• HBGF-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
chemical	0.96
pathway	0.8
disease	0.78
microRNA	0.78

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Fibroblast Growth Factor 2

DTO Classes

Protein / Signaling / Growth Factor / Fibroblast Growth Factor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14113.32   (req: < 5)

Gene RIFs: 710   (req: <= 3)

Antibodies: 1047   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14113.32   (req: >= 5)

Gene RIFs: 710   (req: > 3)

Antibodies: 1047   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 62

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 60

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0