You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HOXC4
Homeobox protein Hox-C4

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303406
  • ENSP00000305973
  • ENSG00000198353
  • ENST00000430889
  • ENSP00000399808

Symbol
  • HOX3E
  • HOX3
  • cp19
  • HOX3E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor
0.76
PubMedID
0.73
virus perturbation
0.72
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.31   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.31   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
1 – 10 of 83
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999999987
p_wrong:  1.2e-8
Data Source:  BioPlex
RABGAP1
Tbio
Family:  Enzyme
Novelty:  0.14270101
p_int:  0.999999083
p_ni:  9.17e-7
Score:  0.191
Data Source:  BioPlex,STRINGDB
RABGAP1L
Tbio
Family:  Enzyme
Novelty:  0.2377644
p_int:  0.999983216
p_ni:  0.000016784
Score:  0.216
Data Source:  BioPlex,STRINGDB
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.999978194
p_ni:  4e-9
p_wrong:  0.000021802
Score:  0.973
Data Source:  BioPlex,STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.999807369
p_ni:  0.000192631
Score:  0.219
Data Source:  BioPlex,STRINGDB
ANKRD17
Tbio
Novelty:  0.03177323
p_int:  0.997303957
p_ni:  0.002696043
Score:  0.181
Data Source:  BioPlex,STRINGDB
ERBIN
Tbio
Novelty:  0.01419561
p_int:  0.996451254
p_ni:  0.003548746
Score:  0.196
Data Source:  BioPlex,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.903050044
p_ni:  0.096949956
Score:  0.191
Data Source:  BioPlex,STRINGDB
HOXC5
Tbio
Family:  TF
Novelty:  0.05354226
Score:  0.982
Data Source:  STRINGDB
HOXC6
Tbio
Family:  TF
Novelty:  0.00991192
Score:  0.978
Data Source:  STRINGDB
Pathways (3)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
12
21
56
98.5
waist circumference
2
16
16
97.7
waist-hip ratio
7
19
23
97.6
BMI-adjusted waist circumference
7
15
26
97.3
5
3
4
1.1
87.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
56
98.5
waist circumference
16
97.7
waist-hip ratio
23
97.6
BMI-adjusted waist circumference
26
97.3
4
1.1
87.1
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96195
15423
Rat
RGD:1586210
24459
Dog
homeobox C4
VGNC:41759
486498
Horse
homeobox C4 [Source:HGNC Symbol;Acc:HGNC:5126]
Cow
homeobox C4
VGNC:29925
613740
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
homeobox C4
Horse
homeobox C4 [Source:HGNC Symbol;Acc:HGNC:5126]
Cow
homeobox C4
Publication Statistics
PubMed Score 52.31
PubMed score by year
PubTator Score 17.58
PubTator score by year